New data from the PRESERVE trial suggest that administration of N-acetylcysteine and/or sodium bicarbonate does not reduce the incidence of acute kidney injury in patients with chronic kidney disease undergoing angiography. Given the limitations of this study, use of these antioxidants should be considered discretionary until further data becomes available.
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Solomon, R. Antioxidants do not PRESERVE kidney function after contrast exposure. Nat Rev Nephrol 14, 148–149 (2018). https://doi.org/10.1038/nrneph.2017.185
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DOI: https://doi.org/10.1038/nrneph.2017.185
