Year in Review

Hypertension in 2017: Novel mechanisms of hypertension and vascular dysfunction

New findings in 2017 enhanced our understanding of the mechanisms that regulate blood pressure. Key studies provided insights into immune mechanisms, the role of the gut microbiota, the adverse effects of perivascular fat and inflammation on the vasculature, and the contribution of rare variants in renin–angiotensin–aldosterone system genes to salt sensitivity.

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    et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension (2017); J. Am. Coll. Cardiol. (2017).

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    et al. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature 496, 513–517 (2013).

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    et al. A salt-sensing kinase in T lymphocytes, SGK1, drives hypertension and hypertensive end-organ damage. JCI Insight 2, e92801 (2017).

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    et al. Salt-responsive gut commensal modulates TH17 axis and disease. Nature 551, 585–589 (2017).

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    et al. Gamma/delta T cells mediate angiotensin II-induced hypertension and vascular injury. Circulation 135, 2155–2162 (2017).

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    et al. Perivascular adipose tissue angiotensin II type 1 receptor promotes vascular inflammation and aneurysm formation. Hypertension 70, 780–789 (2017).

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    et al. Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese. Circ. Cardiovasc. Genet. 6, 598–607 (2013).

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    et al. Resequencing study identifies rare renin–angiotensin–aldosterone system variants associated with blood pressure salt-sensitivity: the GenSalt study. Am. J. Hypertens. 30, 495–501 (2017).

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Acknowledgements

The work of the author was funded by Canadian Institutes of Health Research (CIHR) First Pilot Foundation Grant 143348 and a tier 1 Canada Research Chair on Hypertension and Vascular Research by the Canada Research Chair CIHR/Government of Canada Program.

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Affiliations

  1. Hypertension and Vascular Research Unit, Lady Davis Institute for Medical Research and Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, 3755 Côte-Ste-Catherine Road, Montréal, Québec H3T 1E2, Canada.

    • Ernesto L. Schiffrin

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Correspondence to Ernesto L. Schiffrin.