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Hypertension in 2017

Novel mechanisms of hypertension and vascular dysfunction

New findings in 2017 enhanced our understanding of the mechanisms that regulate blood pressure. Key studies provided insights into immune mechanisms, the role of the gut microbiota, the adverse effects of perivascular fat and inflammation on the vasculature, and the contribution of rare variants in renin–angiotensin–aldosterone system genes to salt sensitivity.

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Figure 1: Novel mechanisms of hypertension and aortic aneurysm formation.


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The work of the author was funded by Canadian Institutes of Health Research (CIHR) First Pilot Foundation Grant 143348 and a tier 1 Canada Research Chair on Hypertension and Vascular Research by the Canada Research Chair CIHR/Government of Canada Program.

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Correspondence to Ernesto L. Schiffrin.

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Schiffrin, E. Novel mechanisms of hypertension and vascular dysfunction. Nat Rev Nephrol 14, 73–74 (2018).

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