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Hypertension in 2017

Novel mechanisms of hypertension and vascular dysfunction

Nature Reviews Nephrology volume 14, pages 73–74 (2018)Cite this article

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New findings in 2017 enhanced our understanding of the mechanisms that regulate blood pressure. Key studies provided insights into immune mechanisms, the role of the gut microbiota, the adverse effects of perivascular fat and inflammation on the vasculature, and the contribution of rare variants in renin–angiotensin–aldosterone system genes to salt sensitivity.

The year 2017 saw the publication of many basic and clinical studies in the field of hypertension as well as new American Heart Association and American College of Cardiology guidelines for the management of high blood pressure in adults1. Here, I focus on key studies that advanced understanding of basic mechanisms of blood pressure regulation and vascular dysfunction, including three studies that provide new insights into the salt sensitivity of blood pressure.

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Figure 1: Novel mechanisms of hypertension and aortic aneurysm formation.

References

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Acknowledgements

The work of the author was funded by Canadian Institutes of Health Research (CIHR) First Pilot Foundation Grant 143348 and a tier 1 Canada Research Chair on Hypertension and Vascular Research by the Canada Research Chair CIHR/Government of Canada Program.

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Authors and Affiliations

  1. Lady Davis Institute for Medical Research and Department of Medicine, Hypertension and Vascular Research Unit, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, 3755 Côte-Ste-Catherine Road, Montréal, H3T 1E2, Québec, Canada

    Ernesto L. Schiffrin

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Correspondence to Ernesto L. Schiffrin.

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Schiffrin, E. Novel mechanisms of hypertension and vascular dysfunction. Nat Rev Nephrol 14, 73–74 (2018). https://doi.org/10.1038/nrneph.2017.178

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  • DOI: https://doi.org/10.1038/nrneph.2017.178

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