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  • Year in Review
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Immune-mediated kidney disease in 2017

Progress in mechanisms and therapy for immunological kidney disease

In 2017, progress was made in several aspects of immune-mediated kidney disease. Mechanistic studies provided new insights into the underlying signals that confer risk to, or protection from, immune pathways, whereas new approaches to the treatment of immunological kidney disease will hopefully translate into a move away from the use of toxic corticosteroids.

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References

  1. Ooi, J. D. et al. Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells. Nature 545, 243–247 (2017).

    Article  CAS  Google Scholar 

  2. Phelps, R. G. & Rees, A. J. The HLA complex in Goodpasture's disease: a model for analyzing susceptibility to autoimmunity. Kidney Int. 56, 1638–1653 (1999).

    Article  CAS  Google Scholar 

  3. Yang, J. J. et al. Circumvention of normal constraints on granule protein gene expression in peripheral blood neutrophils and monocytes of patients with antineutrophil cytoplasmic autoantibody-associated glomerulonephritis. J. Am. Soc. Nephrol. 15, 2103–2114 (2004).

    Article  CAS  Google Scholar 

  4. Jones, B. E. et al. Gene-specific DNA methylation changes predict remission in patients with ANCA-associated vasculitis. J. Am. Soc. Nephrol. 28, 1175–1187 (2017).

    Article  CAS  Google Scholar 

  5. Lyons, P. A. et al. Genetically distinct subsets within ANCA-associated vasculitis. N. Engl. J. Med. 367, 214–223 (2012).

    Article  CAS  Google Scholar 

  6. Lv, J. et al. Effect of oral methylprednisolone on clinical outcomes in patients with IgA nephropathy: the TESTING randomized clinical trial. JAMA 318, 432–442 (2017).

    Article  CAS  Google Scholar 

  7. Fellstrom, B. C. et al. Targeted-release budesonide versus placebo in patients with IgA nephropathy (NEFIGAN): a double-blind, randomised, placebo-controlled phase 2b trial. Lancet 389, 2117–2127 (2017).

    Article  Google Scholar 

  8. Holdsworth, S. R., Gan, P. Y. & Kitching, A. R. Biologics for the treatment of autoimmune renal diseases. Nat. Rev. Nephrol. 12, 217–231 (2016).

    Article  CAS  Google Scholar 

  9. Jayne, D. R. W. et al. Randomized trial of C5a receptor inhibitor avacopan in ANCA-associated vasculitis. J. Am. Soc. Nephrol. 28, 2756–2767 (2017).

    Article  CAS  Google Scholar 

  10. Xiao, H. et al. C5a receptor (CD88) blockade protects against MPO-ANCA GN. J. Am. Soc. Nephrol. 25, 225–231 (2014).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Stephen R. Holdsworth.

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Holdsworth, S., Kitching, A. Progress in mechanisms and therapy for immunological kidney disease. Nat Rev Nephrol 14, 76–78 (2018). https://doi.org/10.1038/nrneph.2017.171

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