Thiazide diuretics lower blood pressure and cardiovascular risk but can cause severe hyponatraemia. Researchers now demonstrate that thiazide-induced hyponatraemia is associated with a genetic variant in a distal nephron prostaglandin transporter. They propose that reduced prostaglandin reabsorption through this transporter facilitates activation of the prostaglandin EP4 receptor to increase water reabsorption.
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Hoorn, E., Wetzels, J. Prostaglandins in thiazide-induced hyponatraemia: do they hold water?. Nat Rev Nephrol 13, 665–666 (2017). https://doi.org/10.1038/nrneph.2017.133
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DOI: https://doi.org/10.1038/nrneph.2017.133