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Transplantation

IdeS to desensitize organ allograft recipients

Nature Reviews Nephrology volume 13, pages 666–668 (2017)Cite this article

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HLA sensitization greatly increases the risk of transplant rejection and failure. An IgG endopeptidase derived from Streptococcus pyogenes (IdeS) may be an attractive new therapy for desensitization. Recent data indicate that IdeS effectively depletes anti-HLA IgG, creating a therapeutic window for successful renal transplantation in sensitized recipients.

Refers to Jordan, S. C. et al. IgG endopeptidase in highly sensitized patients undergoing transplantation. N. Engl. J. Med. 377, 442–453 (2017)

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Figure 1: IdeS is a promising new strategy for desensitization of transplant candidates with donor-specific anti-HLA antibodies.

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Authors and Affiliations

  1. Department of Medicine III, Medical University of Vienna, Währinger Gürtel 18–20, Vienna, A-1090, Austria

    Georg A. Böhmig

  2. Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation, Centre Hospitalier Universitaire Grenoble-Alpes, Avenue du maquis du Grésivaudan, La Tronche, 38700, France

    Lionel Rostaing

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  1. Georg A. Böhmig
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Correspondence to Georg A. Böhmig.

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Competing interests

G.A.B. has received lecture fees from Fresenius and Miltenyi, who provide immunoadsorption devices for antibody depletion in transplantation. L.R. has received lecture fees from Fresenius and HaemaT, who provide apheresis technology for antibody elimination in transplantation.

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Böhmig, G., Rostaing, L. IdeS to desensitize organ allograft recipients. Nat Rev Nephrol 13, 666–668 (2017). https://doi.org/10.1038/nrneph.2017.128

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