HLA sensitization greatly increases the risk of transplant rejection and failure. An IgG endopeptidase derived from Streptococcus pyogenes (IdeS) may be an attractive new therapy for desensitization. Recent data indicate that IdeS effectively depletes anti-HLA IgG, creating a therapeutic window for successful renal transplantation in sensitized recipients.
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G.A.B. has received lecture fees from Fresenius and Miltenyi, who provide immunoadsorption devices for antibody depletion in transplantation. L.R. has received lecture fees from Fresenius and HaemaT, who provide apheresis technology for antibody elimination in transplantation.
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Böhmig, G., Rostaing, L. IdeS to desensitize organ allograft recipients. Nat Rev Nephrol 13, 666–668 (2017). https://doi.org/10.1038/nrneph.2017.128