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Transplantation: IdeS to desensitize organ allograft recipients

HLA sensitization greatly increases the risk of transplant rejection and failure. An IgG endopeptidase derived from Streptococcus pyogenes (IdeS) may be an attractive new therapy for desensitization. Recent data indicate that IdeS effectively depletes anti-HLA IgG, creating a therapeutic window for successful renal transplantation in sensitized recipients.

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Author information

Affiliations

  1. Department of Medicine III, Medical University of Vienna, Währinger Gürtel 18–20, A-1090 Vienna, Austria.

    • Georg A. Böhmig
  2. Service de Néphrologie, Hémodialyse, Aphérèses et Transplantation, Centre Hospitalier Universitaire Grenoble-Alpes, Avenue du maquis du Grésivaudan, 38700 La Tronche, France.

    • Lionel Rostaing

Authors

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Competing interests

G.A.B. has received lecture fees from Fresenius and Miltenyi, who provide immunoadsorption devices for antibody depletion in transplantation. L.R. has received lecture fees from Fresenius and HaemaT, who provide apheresis technology for antibody elimination in transplantation.

Corresponding author

Correspondence to Georg A. Böhmig.