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Hypertension

A new genetic clue to unravel the origins of pre-eclampsia

Nature Reviews Nephrology volume 13, pages 599–600 (2017)Cite this article

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Pre-eclampsia is a common disorder of pregnancy for which the underlying mechanism is poorly understood. A genome-wide association study has now identified a pre-eclampsia susceptibility locus located near the FLT1 gene. This study brings us a step closer to dissecting the underlying causes of pre-eclampsia.

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Figure 1: Pre-eclampsia prevents VEGF signalling in endothelial cells.

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Acknowledgements

This work was supported by US NIH grants HL108618 (J.P.G.), HL51971 (J.P.G.), P20GM104375 (E.M.G.), HL116774 (E.M.G.) and HL137791 (E.M.G).

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Authors and Affiliations

  1. Department of Biochemistry and at the Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, 39216, Mississippi, USA

    Eric M. George

  2. Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 N State St, Jackson, 39216, Mississippi, USA

    Joey P. Granger

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  1. Eric M. George
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  2. Joey P. Granger
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Correspondence to Joey P. Granger.

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The authors declare no competing financial interests.

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George, E., Granger, J. A new genetic clue to unravel the origins of pre-eclampsia. Nat Rev Nephrol 13, 599–600 (2017). https://doi.org/10.1038/nrneph.2017.116

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