The β1 and β2 adrenergic receptors (ARs) are known to contribute to the sympathetic regulation of renal function. Now, researchers report an antidiuretic effect of β3-AR stimulation. In murine kidney tubules, stimulation of β3-AR promoted accumulation of aquaporin 2 at the apical plasma membrane of the collecting duct and activation of the Na-K-2Cl symporter in the thick ascending limb. Moreover, genetic inactivation of β3-AR in mice was associated with significantly increased urine excretion of water, sodium, potassium and chloride, whereas stimulation of β3-AR had the opposite effect.
Procino, G. et al. β3 adrenergic receptor in the kidney may be a new player in sympathetic regulation of renal function. Kidney Int. http://dx.doi.org/10.1016/j.kint.2016.03.020 (2016)
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Carney, E. Role of the β3 adrenergic receptor in renal function. Nat Rev Nephrol 12, 378 (2016). https://doi.org/10.1038/nrneph.2016.80