A new study shows alterations in placental macrophage activation and in their interactions with trophoblasts in women with pre-eclampsia. Przybyl et al. report a significant reduction in CD74+ placental macrophages in pre-eclamptic women compared with healthy controls. Macrophages that lacked CD74 showed reductions in adhesion molecule expression and trophoblast adherence as well as a shift towards a pro-inflammatory signature when co-cultured with trophoblasts. In mice, CD74 knockout resulted in placental abnormalities and fetal growth restriction.
Przybyl, L. et al. CD74-downregulation of placental macrophage-trophoblastic interactions in preeclampsia. Circ. Res. http://dx.doi.org/10.1161/CIRCRESAHA.116.308304 (2016)
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Carney, E. Altered placental macrophages in pre-eclampsia. Nat Rev Nephrol 12, 378 (2016). https://doi.org/10.1038/nrneph.2016.78