Prolyl-4-hydroxylase domain (PHD) dioxygenases are oxygen sensors that regulate hypoxia-inducible factor 2 (HIF-2) and erythropoietin (EPO) production. Now, researchers have shown that renal EPO-producing cells (REPCs) are derived from FOXD1-expressing cells and consist of various subpopulations that are heterogeneous in their response to Phd2 inactivation, regulation of HIF-2 activity, and EPO production. Mouse genetic studies showed that PHD2 is the main regulator of REPC plasticity, which the researchers suggest could be of clinical relevance.
References
Kobayashi, H. et al. Distinct subpopulations of FOXD1 stroma-derived cells regulate renal erythropoietin. J. Clin. Invest. http://dx.doi.org/10.1172/JCI83551 (2016)
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Edwards, J. REPCs are derived from FOXD1 progenitors. Nat Rev Nephrol 12, 316 (2016). https://doi.org/10.1038/nrneph.2016.65
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DOI: https://doi.org/10.1038/nrneph.2016.65
