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Kidney disease and obesity: epidemiology, mechanisms and treatment

Nature Reviews Nephrology volume 13, pages 181–190 (2017)Cite this article

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The theme of World Kidney Day 2017 is 'kidney disease and obesity: healthy lifestyle for healthy kidneys'. To mark this event, Nature Reviews Nephrology invited five leading researchers to describe changes in the epidemiology of obesity-related kidney disease, advances in current understanding of the mechanisms and current approaches to the management of affected patients. The researchers also highlight new advances that could lead to the development of novel treatments and identify areas in which further basic and clinical studies are needed.

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Figure 1: Mechanisms of kidney injury in the setting of obesity.
Figure 2: The influence of lifestyle factors on progression of renal disease.
Figure 3: The fat–intestine–kidney axis.
Figure 4: Interactions between adipose, the microbiome and kidney.
Figure 5: Interactions between the gut and kidney control sodium balance.
Figure 6: Effects of adiponectin on podocyte function.

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Acknowledgements

The authors would like to thank their colleagues in the field and the efforts of the World Kidney Day initiative, for which the focus for 2017 is “kidney disease and obesity: healthy lifestyle for healthy kidneys”.

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Authors and Affiliations

  1. Department of Immunology, Laboratory of Transplantation Immunobiology, Institute of Biomedical Sciences, University of Sao Paulo, Avenue Professor Lineu Prestes 1730, ICB IV, São Paulo, 05508–000, Brazil

    Niels Olsen Saraiva Câmara

  2. Clinical Research Support Center, Tomishiro Central Hospital, Ueda 25, Tomigusuku City, 901–0243, Okinawa, Japan

    Kunitoshi Iseki

  3. Department of Public Health Sciences and Medicine, Division of Nephrology and Hypertension, Loyola University Chicago, 2160 First Avenue, Maywood, 60153, Illinois, USA

    Holly Kramer

  4. National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, 210002, Jiangsu, China

    Zhi-Hong Liu

  5. Center for Renal Translational Medicine, University of California, San Diego and Veterans Affairs San Diego Healthcare System, Stein Clinical Research Building, 4th Floor, 9500 Gilman Drive, La Jolla, 92093–0711, CA, USA

    Kumar Sharma

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  1. Niels Olsen Saraiva Câmara
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All authors contributed equally to the preparation of this manuscript.

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Correspondence to Niels Olsen Saraiva Câmara, Kunitoshi Iseki, Holly Kramer, Zhi-Hong Liu or Kumar Sharma.

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Câmara, N., Iseki, K., Kramer, H. et al. Kidney disease and obesity: epidemiology, mechanisms and treatment. Nat Rev Nephrol 13, 181–190 (2017). https://doi.org/10.1038/nrneph.2016.191

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