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Nephron loss in the ageing kidney — it's more than you think


Nephron number varies widely in healthy adults. The extent to which this variation is due to differences in nephron endowment at birth and/or nephron loss with ageing is unclear. A recent study used a novel approach to identify a previously unappreciated high loss of nephrons with ageing in healthy kidneys.

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Figure 1: Glomerular number estimation.


  1. Hoy, W. E. et al. The early development of the kidney and implications for future health. J. Dev. Orig. Health Dis. 1, 216–233 (2010).

    CAS  Article  PubMed  Google Scholar 

  2. Puelles, V. G et al. Glomerular number and size variability and risk for kidney disease. Curr. Opin. Nephrol. Hypertens. 20, 7–15 (2011).

    Article  PubMed  Google Scholar 

  3. Bertram, J. F., Douglas-Denton, R. N., Diouf, B., Hughson, M. D. & Hoy, W. E. Human nephron number: implications for health and disease. Pediatr. Nephrol. 26, 1529–1533 (2011).

    PubMed  Google Scholar 

  4. Zhang, Z. et al. A common RET variant is associated with reduced newborn kidney size and function. J. Am. Soc. Nephrol. 19, 2027–2034 (2008).

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  5. Denic, A. et al. The substantial loss of nephrons in healthy human kidneys with aging. J. Am. Soc. Nephrol. (2016).

  6. Weibel, E. R. and D. M. Gomez . A principle for counting tissue structures on random sections. J. Appl. Physiol. 17, 343–348 (1962).

    CAS  Article  PubMed  Google Scholar 

  7. Keller, G., Zimmer, G., Mall, G., Ritz, E. & Amann, K. Nephron number in patients with primary hypertension. N. Engl. J. Med. 348, 101–108 (2003).

    Article  PubMed  Google Scholar 

  8. Hayman, J. M., Martin, J. W. & Miller, M. Renal function and the number of glomeruli in the human kidney. Arch. Int. Med. 64, 69–83 (1939).

    Article  Google Scholar 

  9. Hoy, W. E. et al. A stereological study of glomerular number and volume: preliminary studies in a multiracial study of kidneys at autopsy. Kidney Int. 63 (Suppl. 83), S31–S37 (2003).

    Article  Google Scholar 

  10. Beeman, S. C. et al. MRI-based glomerular morphology and pathology in whole human kidneys. Am. J. Physiol. Renal. 306, F1381–F1390 (2014).

    CAS  Article  Google Scholar 

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We acknowledge valuable discussions with Dr. Michael Hughson (Department of Pathology, University of Mississippi Medical Centre) during the preparation of this article.

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Correspondence to John F. Bertram.

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Bertram, J., Hoy, W. Nephron loss in the ageing kidney — it's more than you think. Nat Rev Nephrol 12, 585–586 (2016).

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