New data suggest an important role of the lectin complement pathway in Shiga-toxin-induced renal injury. The researchers used novel human mannose-binding lectin (MBL)-expressing mice that lacked murine Mbls to investigate the role of this pathway in a model of haemolytic uraemic syndrome induced by Shiga-toxin-producing Escherichia coli (STEC–HUS). In these mice, inhibition of MBL — an initiator of the lectin complement pathway — using an anti-MBL2 antibody prevented Shiga toxin-2-induced deposition of the complement component C3d and fibrin in the glomeruli, preserved glomerular filtration rate and attenuated renal injury.