Thrombotic microangiopathy

Inhibition of the lectin complement pathway reduces renal injury in mice with STEC–HUS

New data suggest an important role of the lectin complement pathway in Shiga-toxin-induced renal injury. The researchers used novel human mannose-binding lectin (MBL)-expressing mice that lacked murine Mbls to investigate the role of this pathway in a model of haemolytic uraemic syndrome induced by Shiga-toxin-producing Escherichia coli (STEC–HUS). In these mice, inhibition of MBL — an initiator of the lectin complement pathway — using an anti-MBL2 antibody prevented Shiga toxin-2-induced deposition of the complement component C3d and fibrin in the glomeruli, preserved glomerular filtration rate and attenuated renal injury.

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    Ozaki, M. et al. Human mannose-binding lectin inhibitor prevents Shiga toxin-induced renal injury. Kidney Int. http://dx.doi.org/10.1016/j.kint.2016.05.011 (2016)

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Carney, E. Inhibition of the lectin complement pathway reduces renal injury in mice with STEC–HUS. Nat Rev Nephrol 12, 510 (2016). https://doi.org/10.1038/nrneph.2016.115

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