New data suggest an important role of the lectin complement pathway in Shiga-toxin-induced renal injury. The researchers used novel human mannose-binding lectin (MBL)-expressing mice that lacked murine Mbls to investigate the role of this pathway in a model of haemolytic uraemic syndrome induced by Shiga-toxin-producing Escherichia coli (STEC–HUS). In these mice, inhibition of MBL — an initiator of the lectin complement pathway — using an anti-MBL2 antibody prevented Shiga toxin-2-induced deposition of the complement component C3d and fibrin in the glomeruli, preserved glomerular filtration rate and attenuated renal injury.
References
Ozaki, M. et al. Human mannose-binding lectin inhibitor prevents Shiga toxin-induced renal injury. Kidney Int. http://dx.doi.org/10.1016/j.kint.2016.05.011 (2016)
Rights and permissions
About this article
Cite this article
Carney, E. Inhibition of the lectin complement pathway reduces renal injury in mice with STEC–HUS. Nat Rev Nephrol 12, 510 (2016). https://doi.org/10.1038/nrneph.2016.115
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2016.115