Patients with IgA nephropathy have increased serum levels of undergalactosylated IgA1 (gd-IgA1), which has an established role in the development of the disease. In a new study, Lomax-Browne et al. measured the serum levels of IgA and gd-IgA1 in 148 healthy female twins, including 27 monozygotic and 47 dizygotic pairs. Using the classic twin model, they showed that serum levels of gd-IgA1 are 80% heritable and those of IgA are 46% heritable.
References
Lomax-Browne, H. J. et al. IgA1 glycosylation is heritable in healthy twins. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2016020184 (2016)
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Aguilar, A. Heritability of glycosylated IgA1 levels. Nat Rev Nephrol 12, 444 (2016). https://doi.org/10.1038/nrneph.2016.103
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DOI: https://doi.org/10.1038/nrneph.2016.103