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Access to medications and conducting clinical trials in LMICs


Access to essential medications is limited in many low-to-middle income countries (LMICs) and those that are available may be prohibitively expensive to the general population. Clinical trials have been suggested as an approach to improve drug access in LMICs but the number of trials conducted in these countries is small because of regulatory issues and a lack of infrastructure. In this article, Nature Reviews Nephrology asks three experts their opinions on how to improve drug access and increase the numbers of clinical trials conducted in LMICs.

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Figure 1: Studies on chronic kidney disease registered at on 27 October 2014.14

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F.V.'s work is supported by The U.S. President's Emergency Plan for AIDS Relief.

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Correspondence to Ikechi G. Okpechi, Charles R. Swanepoel or Francois Venter.

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I.G.O. has received travel grants from Roche and Adcock-Ingram. C.R.S. is the Medical Advisor of Fresenius Medical Care, South Africa. He has received honoraria and travel grants from Roche, Amgen, Sanofi and Abbott. F.V. has received speaking fees from Abbot, Gilead, Johnson & Johnson, Merck, Aspen and Adcock Ingram, and is on advisory boards for Mylan and Johnson & Johnson.

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Okpechi, I., Swanepoel, C. & Venter, F. Access to medications and conducting clinical trials in LMICs. Nat Rev Nephrol 11, 189–194 (2015).

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