New findings indicate a role for mitochondrial dynamics in the pathogenesis of cardiorenal syndrome. Sumida et al. found evidence of mitochondrial fragmentation in the hearts of mice 24 h after renal ischaemia–reperfusion injury (IRI). After 72 h, mice had cardiomyocyte apoptosis and cardiac dysfunction. Levels of Drp1, a regulator of mitochondrial fission, were upregulated in the mitochondrial fraction of the heart and administration of a Drp1 inhibitor before IRI decreased mitochondrial fragmentation and ameliorated cardiac dysfunction.
References
Sumida, M. et al. Regulation of mitochondrial dynamics by dynamin-related protein-1 in acute cardiorenal syndrome. J. Am. Soc. Nephrol. 10.1681/ASN.2014080750
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Drp1—a regulator of mitochondrial dynamics in cardiorenal syndrome. Nat Rev Nephrol 11, 196 (2015). https://doi.org/10.1038/nrneph.2015.21
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DOI: https://doi.org/10.1038/nrneph.2015.21
