Over the past decade remote ischaemic preconditioning (RIPC) has evolved as a promising strategy to reduce ischaemia in remote organs. Although previous studies using surrogate outcomes have encouraged further investigation, two recent randomized controlled trials — the ERICCA trial and the RIPHeart Study — were unable to detect a protective effect of RIPC.
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Macedo, E., Mehta, R. Preventing organ dysfunction — is preconditioning still an option?. Nat Rev Nephrol 12, 8–9 (2016). https://doi.org/10.1038/nrneph.2015.192
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DOI: https://doi.org/10.1038/nrneph.2015.192
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