Year in Review | Published:

Acute kidney injury in 2014

A step towards understanding mechanisms of renal repair

Nature Reviews Nephrology volume 11, pages 7475 (2015) | Download Citation

In 2014, key articles in the field of acute kidney injury highlighted the importance of tubular homeostasis in renal regeneration. Cell cycle regulators, inflammatory signals and progenitors were identified as important factors that mediate the balance between inflammation and tubular regeneration necessary for renal repair.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Leçons sur les phénomènes de la vie communs aux animaux et aux végétaux [French], (J. B. Baillière et fils, 1878).

  2. 2.

    et al. Isolation and characterization of progenitor-like cells from human renal proximal tubules. Am. J. Pathol. 178, 828–837 (2011).

  3. 3.

    et al. Origin of regenerating tubular cells after acute kidney injury. Proc. Natl Acad. Sci. USA 111, 1533–1538 (2014).

  4. 4.

    , , , & Differentiated kidney epithelial cells repair injured proximal tubule. Proc. Natl Acad. Sci. USA 111, 1527–1532 (2014).

  5. 5.

    et al. Macrophage phenotype controls long-term AKI outcomes—kidney regeneration versus atrophy. J. Am. Soc. Nephrol. 25, 292–304 (2014).

  6. 6.

    et al. Validation of cell-cycle arrest biomarkers for acute kidney injury using clinical adjudication. Am. J. Respir. Crit. Care Med. 189, 932–939 (2014).

  7. 7.

    et al. Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury. Crit. Care 17, R25 (2013).

  8. 8.

    et al. The association between renal replacement therapy modality and long-term outcomes among critically ill adults with acute kidney injury: a retrospective cohort study. Crit. Care Med. 42, 868–877 (2014).

  9. 9.

    et al. Patient and kidney survival by dialysis modality in critically ill patients with acute kidney injury. Int. J. Artif. Organs 30, 281–292 (2007).

  10. 10.

    et al. A genomic storm in critically injured humans. J. Exp. Med. 208, 2581–2590 (2011).

Download references

Acknowledgements

A.B. is supported by a Center for Sepsis and Critical Illness Award P50 GM-111152 from the National Institute of General Medical Sciences.

Author information

Affiliations

  1. Department of Anaesthesiology, University of Florida, 1600 SW Archer Road, Medical Science Building Room M526B, Gainesville, FL 32610, USA.

    • Azra Bihorac
  2. Center for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh, School of Medicine, Room 604 Scaife Hall, 3550 Terrace Street, Pittsburgh, PA 15261, USA.

    • John A. Kellum

Authors

  1. Search for Azra Bihorac in:

  2. Search for John A. Kellum in:

Competing interests

A.B. has received grant support from Astute Medical. J.A.K. has received grant support and consulting fees from Astute Medical and Baxter.

Corresponding author

Correspondence to John A. Kellum.

About this article

Publication history

Published

DOI

https://doi.org/10.1038/nrneph.2014.245

Further reading

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing