Podocyturia in patients with pre-eclampsia has been widely documented, but the underlying pathology is unknown. A new study highlights the glomerular histological alterations in a unique Dutch cohort of deceased patients with pre-eclampsia. The results suggest an important, albeit controversial, role of parietal epithelial cells in this context.
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References
Garovic, V. D. The role of the podocyte in preeclampsia. Clin. J. Am. Soc. Nephrol. 9, 1337–1340 (2014).
Penning, M. E. et al. Association of preeclampsia with podocyte turnover. Clin. J. Am. Soc. Nephrol. 9, 1377–1385 (2014).
Shankland, S. J., Smeets, B., Pippin, J. W. & Moeller, M. J. The emergence of the glomerular parietal epithelial cell. Nat. Rev. Nephrol. 10, 158–173 (2014).
Smeets, B. et al. Parietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis. J. Am. Soc. Nephrol. 22, 1262–1274 (2011).
Berger, K. et al. The regenerative potential of parietal epithelial cells in adult mice. J. Am. Soc. Nephrol. 25, 693–705 (2014).
Kabgani, N. et al. Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin. PLoS One 7, e34907 (2012).
Wanner, N. et al. Unraveling the role of podocyte turnover in glomerular aging and injury. J. Am. Soc. Nephrol. 25, 707–716 (2014).
Berger, K. & Moeller, M. J. Podocytopenia, parietal epithelial cells and glomerulosclerosis. Nephrol. Dial. Transplant. 29, 948–950 (2014).
Hakroush, S. et al. Extensive podocyte loss triggers a rapid parietal epithelial cell response. J. Am. Soc. Nephrol. 25, 927–938 (2014).
Vikse, B. E., Hallan, S., Bostad, L., Leivestad, T. & Iversen, B. M. Previous preeclampsia and risk for progression of biopsy-verified kidney disease to end-stage renal disease. Nephrol. Dial. Transplant. 25, 3289–3296 (2010).
Acknowledgements
T.S. and M.J.M. are supported by research grants (START) of the medical faculty of the RWTH Aachen and by TP17, SFB/Transregio 57 “Mechanisms of organ fibrosis” of the German Research Foundation (DFG), respectively.
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Saritas, T., Moeller, M. Pre-eclampsia, podocyturia and the role of parietal epithelial cells. Nat Rev Nephrol 10, 615–616 (2014). https://doi.org/10.1038/nrneph.2014.163
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DOI: https://doi.org/10.1038/nrneph.2014.163
