Acute or chronic antibody-mediated rejection (ABMR) of kidney allografts is currently diagnosed by the presence of donor-specific alloantibodies and distinct pathological findings in biopsy samples. A new study highlights the potential of molecular diagnostics incorporated into standard criteria for acute ABMR to help identify patients at risk of graft loss.
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References
Loupy, A. et al. Molecular microscope strategy to improve risk stratification in early antibody-mediated kidney allograft rejection. J. Am. Soc. Nephrol. http://dx.doi.org/10.1681/ASN.2013111149.
Hidalgo, L. G. et al. De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failure. Am. J. Transplant. 9, 2532–2541 (2009).
Haas, M. et al. Banff meeting report: inclusion of C4d-negative antibody-mediated rejection and antibody-associated arterial lesions. Am. J. Transplant. 14, 272–283 (2013).
Sis, B. et al. Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining. Am. J. Transplant. 9, 2312–2323 (2009).
Hidalgo, L. G. et al. NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection. Am. J. Transplant. 10, 1812–1822 (2010).
Sellares, J. et al. Molecular diagnosis of antibody-mediated rejection in human kidney transplants. Am. J. Transplant. 13, 971–983 (2013).
Halloran, P. F. et al. Microarray diagnosis of antibody-mediated rejection in kidney transplant biopsies: an international prospective study (INTERCOM). Am. J. Transplant. 13, 2865–2874 (2013).
Volk, H. D., Sawitzki, B. & Reinke, P. Molecular analysis of renal allograft biopsies—more than a nice toy for researchers? Am. J. Transplant. 13, 539–540 (2013).
Sinn, P. et al. Multigene assays for classification, prognosis, and prediction in breast cancer: a critical review on the background and clinical utility [German]. Geburtshilfe Frauenheilkd. 73, 932–940 (2013).
Acknowledgements
The authors thank Dr Geraldine Rauch at the Institute of Medical Biostatics and Professor Burkhard Tönshoff at the University Children's Hospital, University of Heidelberg, Germany, for helpful discussions.
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Morath, C., Zeier, M. Molecular diagnosis of kidney transplant rejection. Nat Rev Nephrol 10, 429–430 (2014). https://doi.org/10.1038/nrneph.2014.106
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DOI: https://doi.org/10.1038/nrneph.2014.106
