Martini and colleagues recently used a novel genomics approach to assess the functional context of a noncoding variant located near to the promoter of the FRMD3 gene, which is associated with diabetic nephropathy. Their findings suggest a mechanistic link between FRMD3 and diabetic nephropathy that involves the bone morphogenetic protein signalling pathway.
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References
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Palmer, N., Freedman, B. FRMD3 in diabetic nephropathy—guilt by association. Nat Rev Nephrol 9, 313–314 (2013). https://doi.org/10.1038/nrneph.2013.81
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DOI: https://doi.org/10.1038/nrneph.2013.81
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