Online haemodiafiltration is the most advanced dialysis treatment currently available, but widespread implementation of this technique has been delayed pending conclusive evidence of its benefits from randomized studies. The results of the randomized, controlled ESHOL study are now available. Will they change practice?
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Locatelli, F. & Canaud, B. Dialysis adequacy today: a European perspective. Nephrol. Dial. Transplant. 27, 3043–3048 (2012).
Locatelli, F. et al. Effect of membrane permeability on survival of hemodialysis patients. J. Am. Soc. Nephrol. 20, 645–654 (2009).
Locatelli, F. et al. Hemofiltration and hemodiafiltration reduce intradialytic hypotension in ESRD. J. Am. Soc. Nephrol. 21, 1798–1807 (2010).
Canaud, B. et al. Mortality risk for patients receiving hemodiafiltration versus hemodialysis: European results from the DOPPS. Kidney Int. 69, 2087–2093 (2006).
Locatelli, F. et al. Effects of different membranes and dialysis technologies on patient treatment tolerance and nutritional parameters. The Italian Cooperative Dialysis Study Group. Kidney Int. 50, 1293–1302 (1996).
Wizemann, V., Külz, M., Techert, F. & Nederlof, B. Efficacy of haemodiafiltration. Nephrol. Dial. Transplant. 16 (Suppl. 4), 27–30 (2001).
Grooteman, M. P. et al. Effect of online hemodiafiltration on all-cause mortality and cardiovascular outcomes. J. Am. Soc. Nephrol. 23, 1087–1096 (2012).
Ok, E. et al. Mortality and cardiovascular events in online haemodiafiltration (OL-HDF) compared with high-flux dialysis: results from the Turkish OL-HDF Study. Nephrol. Dial. Transplant. http://dx.doi.org/10.1093/ndt/gfs407.
Maduell, F. et al. High-efficiency postdilution online hemodiafiltration reduces all-cause mortality in hemodialysis patients. J. Am. Soc. Nephrol. 24, 487–498 (2013).
Tattersall, J. E., Ward, R. A. & EUDIAL group. Online haemodiafiltration: definition, dose quantification and safety revisited. Nephrol. Dial. Transplant. 28, 542–550 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
F. Locatelli has been a speaker at meetings supported by Bellco, Braun, Fresenius and Gambro–Hospal. W. H. Hörl has been a speaker at meetings supported by Braun and Fresenius.
Rights and permissions
About this article
Cite this article
Locatelli, F., Hörl, W. A step towards making online haemodiafiltration a gold standard. Nat Rev Nephrol 9, 316–318 (2013). https://doi.org/10.1038/nrneph.2013.75
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2013.75