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Pediatrics

When should children surviving a Wilms tumor be transplanted?

Although children with Wilms tumor now have excellent survival rates, some develop end-stage renal disease (ESRD) owing to immediate nephrectomy or later loss of renal function. According to current recommendations, renal transplantation should be delayed for 2 years following Wilms tumor treatment in children, but data from the National Wilms Tumor Study now question such a waiting period.

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References

  1. Pritchard-Jones, K. Controversies and advances in the management of Wilms' tumour. Arch. Dis. Child. 87, 241–244 (2002).

    Article  CAS  Google Scholar 

  2. Levitt, G. Renal tumours: long-term outcome. Pediatr. Nephrol. 27, 911–916 (2012).

    Article  Google Scholar 

  3. Breslow, N. E. et al. End stage renal disease in patients with Wilms tumor: results from the National Wilms Tumor Study Group and the United States Renal Data System. J. Urol. 174, 1972–1975 (2005).

    Article  Google Scholar 

  4. Gellermann, J., Stefanidis, C. J., Mitsioni, A. & Querfeld, U. Successful treatment of steroid-resistant nephrotic syndrome associated with WT1 mutations. Pediatr. Nephrol. 25, 1285–1289 (2010).

    Article  Google Scholar 

  5. Wasilewska, A. M., Kuroczycka-Saniutycz, E. & Zoch-Zwierz, W. Effect of cyclosporin A on proteinuria in the course of glomerulopathy associated with WT1 mutations. Eur. J. Pediatr. 170, 389–391 (2011).

    Article  CAS  Google Scholar 

  6. Stefanidis, C. J. & Querfeld, U. The podocyte as a target: cyclosporin A in the management of the nephrotic syndrome caused by WT1 mutations. Eur. J. Pediatr. 170, 1377–1383 (2011).

    Article  CAS  Google Scholar 

  7. Vats, A. N., Donaldson, L., Fine, R. N. & Chavers, B. M. Pretransplant dialysis status and outcome of renal transplantation in North American children: a NAPRTCS study. North American Pediatric Renal Transplant Cooperative Study. Transplantation 69, 1414–1419 (2000).

    Article  CAS  Google Scholar 

  8. EBPG Expert Group on Renal Transplantation. European best practice guidelines for renal transplantation. Section iv: long-term management of the transplant recipient. IV.1. Organization of follow-up of transplant patients after the first year. Nephrol. Dial. Transplant. 17 (Suppl. 4), 3–4 (2002).

  9. Dome, J. S. & Huff, V. Wilms tumor overview. GeneReviews™ [online], (2003).

    Google Scholar 

  10. Grigoriev, Y. et al. Treatments and outcomes for end-stage renal disease following Wilms tumor. Pediatr. Nephrol. 10.1007/s00467-012-2140-x.

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Correspondence to Uwe Querfeld.

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Querfeld, U., Stefanidis, C. When should children surviving a Wilms tumor be transplanted?. Nat Rev Nephrol 8, 443–444 (2012). https://doi.org/10.1038/nrneph.2012.138

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