Targeting endothelial dysfunction with carvedilol improves intradialytic and interdialytic blood pressure and reduces the frequency of intradialytic hypertension in patients on hemodialysis, according to new findings. In a prospective, 12-week study of 25 hemodialysis patients with intradialytic hypertension, Inrig and colleagues found that carvedilol improved flow-mediated vasodilation. Predialysis systolic blood pressure was unchanged by treatment but postdialysis systolic blood pressure and frequency of intradialytic hypertension were reduced.
ORIGINAL RESEARCH PAPER
Inrig, J. K. et al. Probing the mechanisms of intradialytic hypertension: a pilot study targeting endothelial cell dysfunction. Clin. J. Am. Soc. Nephrol. doi:10.2215/CJN.10010911
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Carvedilol reduces intradialytic hypertension frequency. Nat Rev Nephrol 8, 435 (2012). https://doi.org/10.1038/nrneph.2012.135
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DOI: https://doi.org/10.1038/nrneph.2012.135