Administration of IL-2 complexed to a specific IL-2 monoclonal antibody, JES6–1, is renoprotective in a mouse model of focal segmental glomerulosclerosis, according to new findings. Polhill et al. found that administration of the IL-2/IL-2 antibody complex to mice with adriamycin-induced nephropathy induced the expansion of T-regulatory cells and resulted in improved renal function, reduced inflammation, and reduced histologic injury. They suggest that administration of IL-2/IL-2 antibody complexes could expand T-regulatory cells and treat renal disease in humans.
ORIGINAL RESEARCH PAPER
Polhill, T. et al. IL-2/IL-2Ab complexes induce regulatory T cell expansion and protect against proteinuric CKD. J. Am. Soc. Nephrol. doi:10.1681/ASN.2011111130
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Renoprotection by IL-2/IL-2 antibody complexes. Nat Rev Nephrol 8, 434 (2012). https://doi.org/10.1038/nrneph.2012.129
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DOI: https://doi.org/10.1038/nrneph.2012.129