A prospective, observational study has found that the ratio of total-to-ionized calcium independently predicts mortality in critically ill patients with acute kidney injury receiving continuous renal replacement therapy with regional citrate anticoagulation. The researchers found that a ratio of total-to-ionized calcium ≥2.4 was associated with a 33.5-fold increase in 28-day mortality. A significant correlation was also found between total-to-ionized calcium ratio, hepatic clearance and severity of critical illness.
ORIGINAL RESEARCH PAPER
Link, A. et al. Total to ionized calcium ratio predicts mortality in continuous renal replacement therapy with citrate anticoagulation in critically ill patients. Crit. Care doi:10.1186/cc11363
Rights and permissions
About this article
Cite this article
Ratio of total-to-ionized calcium and mortality risk. Nat Rev Nephrol 8, 434 (2012). https://doi.org/10.1038/nrneph.2012.128
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2012.128