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Acute kidney injury in 2011

Biomarkers are transforming our understanding of AKI

Nature Reviews Nephrology volume 8, pages 68–70 (2012)Cite this article

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Acute kidney injury (AKI) is a syndrome of decreased renal function that is associated with an increased risk of death. Studies from 2011, particularly in the field of AKI biomarkers, have provided important insights into the diagnosis, prognosis, and treatment of AKI. These advances are now being brought to the bedside to improve diagnosis and treatment of AKI.

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References

  1. Hoste, E. A. et al. Epidemiology of acute kidney injury. Contrib. Nephrol. 165, 1–8 (2010).

    Article  Google Scholar 

  2. Chawla, L. S., Amdur, R. L., Amodeo, S., Kimmel, P. L. & Palant, C. E. The severity of acute kidney injury predicts progression to chronic kidney disease. Kidney Int. 79, 1361–1369 (2011).

    Article  Google Scholar 

  3. Ishani, A. et al. The magnitude of acute serum creatinine increase after cardiac surgery and the risk of chronic kidney disease, progression of kidney disease, and death. Arch. Intern. Med. 171, 226–233 (2011).

    Article  Google Scholar 

  4. Paragas, N. et al. The Ngal reporter mouse detects the response of the kidney to injury in real time. Nat. Med. 17, 216–222 (2011).

    Article  CAS  Google Scholar 

  5. Shemin, D. & Dworkin, L. D. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for early acute kidney injury. Crit. Care Clin. 27, 379–389 (2011).

    Article  CAS  Google Scholar 

  6. Srisawat, N. et al. Plasma neutrophil gelatinase-associated lipocalin predicts recovery from acute kidney injury following community-acquired pneumonia. Kidney Int. 80, 545–552 (2011).

    Article  CAS  Google Scholar 

  7. Macedo, E., Malhotra, R., Bouchard, J., Wynn, S. K. & Mehta, R. L. Oliguria is an early predictor of higher mortality in critically ill patients. Kidney Int. 80, 760–767 (2011).

    Article  CAS  Google Scholar 

  8. Lorenzen, J. M. et al. Circulating miR-210 predicts survival in critically ill patients with acute kidney injury. Clin. J. Am. Soc. Nephrol. 6, 1540–1546 (2011).

    Article  CAS  Google Scholar 

  9. Fasanaro, P. et al. MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3. J. Biol. Chem. 283, 15878–15883 (2008).

    Article  CAS  Google Scholar 

  10. Munshi, R. et al. MCP-1 gene activation marks acute kidney injury. J. Am. Soc. Nephrol. 22, 165–175 (2011).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Anesthesiology and Critical Care Medicine, George Washington University Hospital, 900 23rd Street, NW Room G-105, 20037, Washington DC, USA

    Lakhmir S. Chawla

  2. Department of Critical Care Medicine, 604 Scaife Hall, University of Pittsburgh, 3550 Terrace Street, Pittsburgh, 15261, PA, USA

    John A. Kellum

Authors
  1. Lakhmir S. Chawla
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  2. John A. Kellum
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Correspondence to John A. Kellum.

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Competing interests

L. S. Chawla declares associations with the following companies: Abbott (consultant), Alere (consultant, grant/research support), Astute Medical (consultant, grant/research support). J. A. Kellum declares associations with the following companies: Abbott (consultant), Alere (consultant, grant/research support), Astute Medical (consultant, grant/research support), Roche (consultant).

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Chawla, L., Kellum, J. Biomarkers are transforming our understanding of AKI. Nat Rev Nephrol 8, 68–70 (2012). https://doi.org/10.1038/nrneph.2011.216

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