Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

End-stage renal disease

A new comorbidity index for estimating mortality risk in ESRD

Nature Reviews Nephrology volume 6, pages 391–393 (2010)Cite this article

Subjects

A new comorbidity index predicts the risk of mortality in patients with end-stage renal disease (ESRD). This index, which was developed using data from a large US database, is an important tool for observational research in patients with ESRD, but its value in patient populations other than dialysis populations in the US needs to be validated.

“...a critical appraisal of this index is needed with regard to its potential limitations”

This is a preview of subscription content

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

Buy

All prices are NET prices.

References

  1. de Jager, D. J. et al. Cardiovascular and noncardiovascular mortality among patients starting dialysis. JAMA 302, 1782–1789 (2009).

    CAS  Article  Google Scholar 

  2. Verdalles, U. et al. Factors predicting mortality in elderly patients on dialysis. Nephron Clin. Pract. 115, c28–c34 (2010).

    CAS  Article  Google Scholar 

  3. van Manen, J. G. et al. How to adjust for comorbidity in survival studies in ESRD patients: a comparison of different indices. Am. J. Kidney Dis. 40, 82–89 (2002).

    Article  Google Scholar 

  4. Charlson, M. E., Pompei, P., Ales, K. L. & MacKenzie, C. R. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J. Chronic Dis. 40, 373–383 (1987).

    CAS  Article  Google Scholar 

  5. Khan, I. et al. Influence of coexisting disease on survival on renal-replacement therapy. Lancet 341, 415–418 (1993).

    CAS  Article  Google Scholar 

  6. Davies, S. J., Russell, L., Bryan, J., Phillips, L. & Russell, G. I. Comorbidity, urea kinetics, and appetite in continuous ambulatory peritoneal dialysis patients: their interrelationship and prediction of survival. Am. J. Kidney Dis. 26, 353–361 (1995).

    CAS  Article  Google Scholar 

  7. Liu, J., Huang, Z., Gilbertson, D. T., Foley, R. N. & Collins, A. J. An improved comorbidity index for outcome analyses among dialysis patients. Kidney Int. 77, 141–151 (2010).

    Article  Google Scholar 

  8. Seliger, S. L. Comorbidity and confounding in end-stage renal disease. Kidney Int. 77, 83–85 (2010).

    Article  Google Scholar 

  9. Miskulin, D. et al. Key comorbid conditions that are predictive of survival among hemodialysis patients. Clin. J. Am. Soc. Nephrol. 4, 1818–1826 (2010).

    Article  Google Scholar 

  10. Stenvinkel, P. et al. Emerging biomarkers for evaluating cardiovascular risk in the chronic kidney disease patient: how do new pieces fit into the uremic puzzle? Clin. J. Am. Soc. Nephrol. 3, 505–521 (2008).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

  1. Divisions of Baxter Novum and Renal Medicine, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, K56 Karolinska University Hospital Huddinge, S-141 86, Stockholm, Sweden

    Bengt Lindholm

  2. Department of Nephrology, Keele University, University Hospital of North Staffordshire, Royal Infirmary, Princess Road, Stoke on Trent, ST4 7LN, Staffordshire, UK

    Simon Davies

Authors
  1. Bengt Lindholm
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Simon Davies
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Bengt Lindholm.

Ethics declarations

Competing interests

B. Lindholm declares an association with the following company: Baxter Healthcare Corporation, as a consultant, recipient of grant/research support, and stockholder/director. S. Davis declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lindholm, B., Davies, S. A new comorbidity index for estimating mortality risk in ESRD. Nat Rev Nephrol 6, 391–393 (2010). https://doi.org/10.1038/nrneph.2010.81

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nrneph.2010.81

Further reading

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing