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Results of RENAL—what is the optimal CRRT target dose?

Nature Reviews Nephrology volume 6, pages 191–192 (2010)Cite this article

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The abstract of the RENAL Replacement Therapy study concludes that in critically ill patients with acute kidney injury, treatment with higher-intensity continuous renal replacement therapy did not reduce mortality. However, the real news is that survival and recovery of renal function might depend on how therapy is provided.

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Figure 1: Relationship between delivered RRT intensity and survival in critically ill patients with acute kidney injury (AKI).

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Authors and Affiliations

  1. Department of Critical Care Medicine, The CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute Illness) Laboratory, University of Pittsburgh Medical Center, 3550 Terrace Street, Pittsburgh, 15261, PA, USA

    John A. Kellum

  2. Department of Nephrology, Dialysis, Transplantation, San Bortolo Hospital and International Renal Research Institute, Via Rodolfi, 37, Vicenza, 36100, Italy

    Claudio Ronco

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  1. John A. Kellum
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  2. Claudio Ronco
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Correspondence to John A. Kellum.

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Competing interests

J. A. Kellum declares associations with Baxter International, Fresenius and Gambro, as consultant, recipient of honoraria from the speakers bureau and as recipient of grant/research support. C. Ronco declares no competing interests.

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Kellum, J., Ronco, C. Results of RENAL—what is the optimal CRRT target dose?. Nat Rev Nephrol 6, 191–192 (2010). https://doi.org/10.1038/nrneph.2010.15

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