The degree to which systolic blood pressure should be lowered in individuals with mild hypertension is unclear. The Cardio-Sis trial has investigated whether tight systolic blood pressure control is more beneficial than usual control in individuals with hypertension but without diabetes.
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Johnson, R., Sánchez-Lozada, L. & Rodríguez-Iturbe, B. New treatment target for systolic blood pressure?. Nat Rev Nephrol 5, 675–676 (2009). https://doi.org/10.1038/nrneph.2009.188
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DOI: https://doi.org/10.1038/nrneph.2009.188