Abstract
Functional imaging gives us increasingly detailed information about the location of brain activity. To use this information, we need a clear conception of the meaning of location data. Here, we review methods for reporting location in functional imaging and discuss the problems that arise from the great variability in brain anatomy between individuals. These problems cause uncertainty in localization, which limits the effective resolution of functional imaging, especially for brain areas involved in higher cognitive function.
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Acknowledgements
Many thanks to T. Hackett and M. Petrides for helpful discussions on cytoarchitecture, and to J. Ashburner, S. Baxendale, D. Bor, J. Collins, L. Collins, R. Cools, M. Davis, G. DiGirolamo, J. Duncan, A. Gazanfar, A. Lawrence and T. Marcel for comments on earlier drafts of this paper.
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Brett, M., Johnsrude, I. & Owen, A. The problem of functional localization in the human brain. Nat Rev Neurosci 3, 243–249 (2002). https://doi.org/10.1038/nrn756
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DOI: https://doi.org/10.1038/nrn756
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