The neural bases of emotion regulation

Abstract

Emotions are powerful determinants of behaviour, thought and experience, and they may be regulated in various ways. Neuroimaging studies have implicated several brain regions in emotion regulation, including the ventral anterior cingulate and ventromedial prefrontal cortices, as well as the lateral prefrontal and parietal cortices. Drawing on computational approaches to value-based decision-making and reinforcement learning, we propose a unifying conceptual framework for understanding the neural bases of diverse forms of emotion regulation.

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Figure 1: A valuation perspective on emotional reactivity and regulation.
Figure 2: Regions implicated in emotion regulation.
Figure 3: Schematic of model-based and model-free emotion regulation.
Figure 4: Example of emotion regulation as a decision-making process.

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Acknowledgements

A.E. is funded by the Sierra-Pacific Mental Illness Research, Education and Clinical Center (MIRECC) at the Veterans Affairs Palo Alto Healthcare System. A.E. and J.J.G. are funded by US National Institutes of Health grants R01MH091860 and R21MH097984. C.B. is funded by European Research Council (ERC) grant ERC-2010-AdG_20100407 and the German Research Foundation (DFG; SFB TRR 58).

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Glossary

Computational modelling

The application of algorithms representing functions computed by the brain to explain observed behaviour through latent variables.

Conditioned stimulus

(CS). A previously neutral stimulus that takes on aversive or rewarding properties after being associated with an unconditioned stimulus.

Limbic regions

Deep brain structures (for example, the amygdala, ventral striatum and brain stem nuclei) involved in emotional and motivational processes.

Prediction errors

Discrepancies between experienced stimuli and expectations about them.

Reinforcement learning

An area of study describing changes in behaviour driven by the experience of rewards or punishments.

Transcranial magnetic stimulation

(TMS). A method for non-invasive stimulation of the brain using a focal pulsed magnetic field, which can be used to excite or inhibit brain activity.

Unconditioned stimulus

(US). A naturally aversive or rewarding stimulus.

Value

A dimensionless 'universal currency' that denotes the relative 'good for me' or 'bad for me' motivational relevance of a stimulus or action.

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Etkin, A., Büchel, C. & Gross, J. The neural bases of emotion regulation. Nat Rev Neurosci 16, 693–700 (2015). https://doi.org/10.1038/nrn4044

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