A new mechanism of nervous system plasticity: activity-dependent myelination

Article metrics

Abstract

The synapse is the focus of experimental research and theory on the cellular mechanisms of nervous system plasticity and learning, but recent research is expanding the consideration of plasticity into new mechanisms beyond the synapse, notably including the possibility that conduction velocity could be modifiable through changes in myelin to optimize the timing of information transmission through neural circuits. This concept emerges from a confluence of brain imaging that reveals changes in white matter in the human brain during learning, together with cellular studies showing that the process of myelination can be influenced by action potential firing in axons. This Opinion article summarizes the new research on activity-dependent myelination, explores the possible implications of these studies and outlines the potential for new research.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Development of oligodendrocytes.
Figure 2: Myelin and the node of Ranvier.
Figure 3: Changes in white matter tracts after learning.
Figure 4: Non-synaptic junctions on myelinating glia promote preferential myelination of electrically active axons.
Figure 5: Myelin stabilization is promoted by vesicle release from axons in zebrafish.
Figure 6: Activity-dependent myelination in nervous system plasticity and learning.

References

  1. 1

    Fields, R. D. in Neuroglia 3rd edn (eds Kettenmann, H. & Ransom, B. R.) 573–585 (Oxford Univ. Press, 2013).

  2. 2

    Fields, R. D. White matter in learning, cognition and psychiatric disorders. Trends Neurosci. 31, 361–370 (2008).

  3. 3

    Yakovlev, P. I. & Lecours, A.-R. in Regional Development of the Brain in Early Life (ed. Minkowski, A.) 3–70 (Blackwell Scientific, 1987).

  4. 4

    Mabbott, D. J., Noseworthy, M., Bouffet, E., Laughlin, S. & Rockel, C. White matter growth as a mechanism of cognitive development in children. Neuroimage 33, 936–946 (2006).

  5. 5

    Nagy, Z. et al. Maturation of white matter is associated with the development of cognitive functions during childhood. J. Cogn. Neurosci. 16, 1227–1233 (2004).

  6. 6

    Kraft, R. H., Mitchell, O. R., Languis, M. L. & Wheatley, G. H. Hemispheric asymmetries during six- to eight-year-olds performance of Piagetian conservation and reading tasks. Neuropsychologia 18, 637–643 (1980).

  7. 7

    Pujol, J. et al. Myelination of language-related areas in the developing brain. Neurology 66, 339–343 (2006).

  8. 8

    Liston, C. et al. Frontostriatal microstructure modulates efficient recruitment of cognitive control. Cereb. Cortex 16, 553–560 (2006).

  9. 9

    Giedd, J. N. Structural magnetic resonance imaging of the adolescent brain. Ann. NY Acad. Sci. 1021, 77–85 (2004).

  10. 10

    Schrager, P. & Novakovic, S. D. Control of myelination, axonal growth, and synapse formation in spinal cord explants by ion channels and electrical activity. Brain Res. Dev. Brain Res. 88, 68–78 (1995).

  11. 11

    Demerens, C. et al. Induction of myelination in the central nervous system by electrical activity. Proc. Natl Acad. Sci. USA 93, 9887–9892 (1996).

  12. 12

    Stevens, B., Tanner, S. & Fields, R. D. Control of myelination by specific patterns of neural impulses. J. Neurosci. 18, 9303–9311 (1998).

  13. 13

    Stevens, B., Porta, S., Haak, L. L., Gallo, V. & Fields, R. D. Adenosine: a neuron-glial transmitter promoting myelination in the CNS in response to action potentials. Neuron 36, 855–868 (2002).

  14. 14

    Stevens, B., Ishibashi, T., Chen, J. F. & Fields, R. D. Adenosine: an activity-dependent axonal signal regulating MAP kinase and proliferation in developing Schwann cells. Neuron Glia Biol. 1, 23–34 (2004).

  15. 15

    Ishibashi, T. et al. Astrocytes promote myelination in response to electrical impulses. Neuron 49, 823–823 (2006).

  16. 16

    Wake, H., Lee, P. R. & Fields, R. D. Control of local protein synthesis and initial events in myelination by action potentials. Science 333, 1647–1651 (2011).

  17. 17

    Yang, I. H. et al. Axon myelination and electrical stimulation in a microfluidic compartmentalized cell culture platform. Neuromolecular Med. 14, 112–118 (2012).

  18. 18

    Malone, M. et al. Neuronal activity promotes myelination via a cAMP pathway. Glia 61, 843–854 (2013).

  19. 19

    Luundgard, L. et al. Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes. PLoS Biol. 11, e1001743 (2013).

  20. 20

    Dan, Y. & Poo, M. M. Spike timing-dependent plasticity: from synapse to perception. Physiol. Rev. 86, 1033–1048 (2006).

  21. 21

    Fields, R. D. Myelination: an overlooked mechanism of synaptic plasticity? Neuroscientist 11, 528–531 (2005).

  22. 22

    Buzsáki, G. Rhythms of the Brain (Oxford Univ. Press, 2006).

  23. 23

    Ainsworth, M. et al. Rates and rhythms: a synergistic view of frequency and temporal coding in neuronal networks. Neuron 75, 572–583 (2012).

  24. 24

    Nunez, P. L. Srinivasan, R. & Fields, R. D. EEG functional connectivity, axon delays and white matter disease. Clin. Neurophysiol. 126, 110–120 (2015).

  25. 25

    Pajevic, S., Basser, P. J. & Fields, R. D. Role of myelin plasticity in oscillations and synchrony of neuronal activity. Neuroscience 276, 135–147 (2014).

  26. 26

    Zatorre, R. J., Fields, R. D. & Johansen-Berg, H. Plasticity in gray and white: neuroimaging changes in brain structure during learning. Nat. Neurosci. 15, 528–536 (2012).

  27. 27

    Bengtsson, S. L. et al. Extensive piano practicing has regionally specific effects on white matter development. Nat. Neurosci. 8, 1148–1150 (2005).

  28. 28

    Carreiras, M. et al. An anatomical signature for literacy. Nature 461, 983–986 (2009).

  29. 29

    Scholz, J., Klein, M. C., Behrens, T. E. & Johansen-Berg, H. Training induces changes in white-matter architecture. Nat. Neurosci. 12, 1370–1371 (2009).

  30. 30

    Fields, R. D. Imaging learning: The search for a memory trace. Neuroscientist 17, 185–196 (2011).

  31. 31

    Gibson, E. M. et al. Neuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain. Science 344, 1252304 (2014).

  32. 32

    Hines, H. H., Ravanelli, A. M., Schwindt, R., Scott, E. K. & Appel, B. Neuronal activity biases axon selection for myelination in vivo. Nat. Neurosci. 18, 683–689 (2015).

  33. 33

    Mensch, S. et al. Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo. Nat. Neurosci. 18, 628–630 (2015).

  34. 34

    Swadlow, H. A. Physiological properties of individual cerebral axons studied in vivo for as long as one year. J. Neurophysiol. 54, 1346–1362 (1985).

  35. 35

    Liu, J. et al. Impaired adult myelination in the prefrontal cortex of socially isolated mice. Nat. Neurosci. 15, 1621–1623 (2012).

  36. 36

    Makinodan, M., Rosen, K. M., Ito, S. & Corfas, G. A critical period for social experience-dependent oligodendrocyte maturation and myelination. Science 337, 1357–1360 (2012).

  37. 37

    Okuda, H. et al. Environmental enrichment stimulates progenitor cell proliferation in the amygdala. J. Neurosci. Res. 87, 3546–3553 (2009).

  38. 38

    Zhao, U. Y. et al. Enriched environment increases the total number of CNPase positive cells in the corpus callosum of middle-aged rats. Acta Neurobiol. Exp. 71, 322–330 (2011).

  39. 39

    Simon, C., Gotz, M. & Dimou, L. Progenitors in adult cerebral cortex: cell cycle properties and regulation by physiological stimuli and injury. Glia 59, 869–881 (2011).

  40. 40

    McKenzie, I. et al. Motor skill learning requires central myelination. Science 346, 318–322 (2014).

  41. 41

    Blumenfeld-Katzir, T., Pasternak, O., Dagan, M. & Assaf, Y. Diffusion MRI of structural brain plasticity induced by a learning and memory task. PLoS ONE 6, e20678 (2011).

  42. 42

    Kleim, J. A. et al. Motor learning-dependent synaptogenesis is localized to functionally reorganized motor cortex. Neurobiol. Learn. Mem. 77, 63–77 (2002).

  43. 43

    Sampaio-Baptista, C. et al. Motor skill learning induces changes in white matter microstructure and myelination. J. Neurosci. 33, 19499–19503 (2013).

  44. 44

    Hofstetter, S., Tavor, I., Moryosef, S. T. & Assaf, Y. Short-term learning induces white matter plasticity in the fornix. J. Neurosci. 33, 12844–12850 (2013).

  45. 45

    Yang, S. et al. Effects of an enriched environment on myelin sheaths in the white matter of rats during normal aging: A stereological study. Neuroscience 234, 13–21 (2013).

  46. 46

    Engvig, A. et al. Memory training impacts short-term changes in aging white matter: a longitudinal diffusion tensor imaging study. Hum. Brain Mapp. 33, 2390–2406 (2012).

  47. 47

    Engvig, A. et al. Effects of memory training on cortical thickness in the elderly. Neuroimage 52, 667–1676 (2010).

  48. 48

    Kennedy, K. M. & Raz, N. Aging white matter and cognition: Differential effects of regional variations in diffusion properties on memory, executive funcitons, and speed. Neuropsychologia 47, 916–927 (2009).

  49. 49

    Marner, L., Nyengaard, J. R., Tang, Y. & Pakkenberg, B. Marked loss of myelinated nerve fibers in the human brain with age. J. Comp. Neurol. 462, 144–152 (2003).

  50. 50

    Salat, D. H. et al. Age-related alterations in white matter microstructure measured by diffusion tensor imaging. Neurobiol. Aging 26, 1215–1227 (2005).

  51. 51

    Bartzokis, G. Age-related myelin breakdown: A developmental model of cognitive decline and Alzheimer's disease. Neurobiol. Aging 25, 5–18 (2004).

  52. 52

    Ransom, B. R. & Orkand, R. K. Glial-neuronal interactions in non-synaptic areas of the brain: studies in the optic nerve. Trends Neurosci. 19, 352–358 (1996).

  53. 53

    Káradóttir, R., Cavelier, P., Bergersen, L. H. & Attwell, D. NMDA receptors are expressed in oligodendrocytes and activated in ischaemia. Nature. 438, 1162–1166 (2005).

  54. 54

    Stevens, B. & Fields, R. D. Response of Schwann cells to action potentials in development. Science. 287, 2267–2271 (2000).

  55. 55

    Gallo, V. et al. Oligodendrocyte progenitor cell proliferation and lineage progression are regulated by glutamate receptor-mediated K1 channel block. J. Neurosci. 16, 2659–2670 (1996).

  56. 56

    Mangin, J. M., Li, P., Scafidi, J. & Gallo, V. Experience-dependent regulation of NG2 progenitors in the developing barrel cortex. Nat. Neurosci. 15, 1192–1194 (2012).

  57. 57

    Zonouzi, M. et al. GABAergic regulation of cerebellar NG2 cell development is altered in perinatal white matter injury. Nat. Neurosci. 18, 674–682 (2015).

  58. 58

    Fields, R. D. Nonsynaptic and nonvesicular ATP release from neurons and relevance to neuron–glia signaling. Semin. Cell Dev. Biol. 22, 214–219 (2011).

  59. 59

    Burnstock, G. Physiology and pathophysiology of purinergic neurotransmission. Physiol. Rev. 87, 659–797 (2007).

  60. 60

    Zhang, Z. W., Kang, J. I. & Vaucher, E. Axonal varicosity density as an index of local neuronal interactions. PLoS ONE 6, e22543 (2011).

  61. 61

    Kriegler, S. & Chiu, S. Y. Calcium signaling of glial cells along mammalian axons. J. Neurosci. 13, 4229–4245 (1993).

  62. 62

    Orkand, R. K., Nicholls, J. G. & Kuffler, S. W. Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia. J. Neurophysiol. 29, 788–806 (1966).

  63. 63

    Fields, R. D. & Ni, Y. Nonsynaptic communication through ATP release from volume-activated anion channels in axons. Sci. Signal. 3, ra73 (2010).

  64. 64

    Fields, R. D. Imaging single photons and intrinsic optical signals for studies of vesicular and non-vesicular ATP release from axons. Front. Neuroanat. 5, 32 (2011).

  65. 65

    Micu, I. et al. NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature 439, 988–992 (2006).

  66. 66

    Butt, A. M., Fern, R. F. & Matute, C. Neurotransmitter signaling in white matter. Glia. 62, 1762–1779 (2014).

  67. 67

    Fern, R. F., Matute, C. & Stys, P. K. White matter injury: Ischemic and nonischemic. Glia 62, 1780–1789 (2014).

  68. 68

    Garthwaite, G., Hampden-Smith, K., Wilson, G. W., Goodwin, D. A. & Garthwaite, J. Nitric oxide targets oligodendrocytes and promotes their morphological differentiation. Glia 63, 383–399 (2015).

  69. 69

    Itoh, K., Stevens, B., Schachner, M. & Fields, R. D. Regulated expression of the neural cell adhesion molecule L1 by specific patterns of neural impulses. Science. 270, 1369–1372 (1995).

  70. 70

    Itoh, K., Ozaki, M., Stevens, B. & Fields, R. D. Activity-dependent regulation of N-cadherin in DRG neurons: differential regulation of N-cadherin, NCAM, and L1 by distinct patterns of action potentials. J. Neurobiol. 33, 735–748 (1997).

  71. 71

    Yuen, T. J. et al. Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis. Cell. 158, 383–396 (2014).

  72. 72

    Bergles, D. E., Roberts, J. D., Somogyi, P. & Jahr, C. E. Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus. Nature. 405, 187–191 (2000).

  73. 73

    Horner, P. J. et al. Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. J. Neurosci. 20, 2218–2228 (2000).

  74. 74

    Dawson, M. R. L., Polito, A., Levine, J. M. & Reynolds, R. NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS. Mol. Cell. Neurosci. 24, 476–488 (2003).

  75. 75

    Young, K. M. et al. Oligodendrocyte dynamics in healthy adult CNS: evidence for myelin remodeling. Neuron 77, 873–853 (2013).

  76. 76

    Lin, S. C. et al. Climbing fiber innervation of NG2-expressing glia in the mammalian cerebellum. Neuron. 46, 773–785 (2005).

  77. 77

    Kukley, M., Capetillo-Zarate, E. & Dietrich, D. Vesicular glutamate release from axons in white matter. Nat. Neurosci. 10, 311–320 (2007).

  78. 78

    Kukley, M. et al. Glial cells are born with synapses. FASEB J. 22, 2957–2969 (2008).

  79. 79

    Maldonado, P. P., Velez-Fort, M. & Angulo, M. C. Is neuronal communication with NG2 cells synaptic or extrasynaptic? J. Anat. 219, 8–17 (2011).

  80. 80

    Wake, H. et al. Non-synaptic junctions on myelinating glia promote preferential myelination of electrically-active axons. Nat. Commun. 6, 7844 (2015).

  81. 81

    Sakry, D. et al. Oligodendrocyte precursor cells modulate the neuronal network by activity-dependent ectodomain cleavage of NG2. PLoS Biol 12, 1001–1092 (2014).

  82. 82

    Bakhti, M., Winter, C. & Simons, M. Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles. J. Biol. Chem. 286, 787–796 (2011).

  83. 83

    Frühbeis, C. et al. Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication. PLoS Biol. 11, e1001604 (2013).

  84. 84

    Pusic, A. D. & Kraig, R. P. Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination. Glia 62, 284–299 (2014).

  85. 85

    Luse, S. A. in The Biology of Myelin (ed. Korey, S. R.) 59 (Paul B. Hoeber, 1959).

  86. 86

    Krämer, E. M., Klein, C., Koch, T., Boytinck, M. & Trotter, J. Compartmentation of Fyn kinase with glycosylphosphatidylinositol-anchored molecules in oligodendrocytes facilitates kinase activation during myelination. J. Biol. Chem. 274, 29042–29049 (1999).

  87. 87

    Laursen, L. S., Chan, C. W. & ffrench-Constant, C. An integrin-contactin complex regulates CNS myelination by differential Fyn phosphorylation. J. Neurosci. 29, 9174–9185 (2009).

  88. 88

    White, R. et al. Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2-dependent RNA granules. J. Cell Biol. 181, 579–586 (2008).

  89. 89

    Barbin, G. et al. Axonal cell-adhesion molecule L1 in CNS myelination. Neuron Glia Biol. 1, 65–72 (2004).

  90. 90

    Seilheimer, B., Persohn, E. & Schachner, M. Neural cell adhesion molecule expression is regulated by Schwann cell-neuron interactions in culture. J. Cell Biol. 108, 1909–1915 (1989).

  91. 91

    Wood, P. M., Schachner, M. & Bunge, R. P. Inhibition of Schwann cell myelination in vitro by antibody to the L1 adhesion molecule. J. Neurosci. 10, 3635–3645 (1990).

  92. 92

    Chiu, S. Y. & Wilson, G. F. The role of potassium channels in Schwann cell proliferation in Wallerian degeneration of explant rabbit sciatic nerves. J. Physiol. 408, 199–222 (1989).

  93. 93

    Pappas, C. A., Ullrich, N. & Sontheimer, H. Reduction of glial proliferation by K+ channel blockers is mediated by changes in pH. Neuroreport 6, 193–196 (1994).

  94. 94

    Knutson, P. et al. K+ channel expression and cell proliferation are regulated by intracellular sodium and membrane depolarization in oligodendrocyte progenitor cells. J. Neurosci. 17, 2669–2682 (1997).

  95. 95

    Gudz, T. I., Komuro, H. & Macklin, W. B. Glutamate stimulates oligodendrocyte progenitor migration mediated via an alphav integrin/myelin proteolipid protein complex. J. Neurosci. 26, 2458–2466 (2006).

  96. 96

    Xiao, L. et al. NMDA receptor couples Rac1-GEF Tiam1 to direct oligodendrocyte precursor cell migration. Glia. 61, 2078–2099 (2013).

  97. 97

    Fields, R. D. & Burnstock, G. Purinergic signaling in neuron-glia interactions. Nat. Rev. Neurosci. 7, 423–436 (2006).

  98. 98

    Barres, B. A. & Raff, M. C. Proliferation of oligodendrocyte precursor cells depends on electrical activity in axons. Nature. 361, 258–260 (1993).

  99. 99

    Van't Veer, A. et al. Brain-derived neurotrophic factor effects on oligodendrocyte progenitors of the basal forebrain are mediated through trkB and the MAP kinase pathway. J. Neurosci. Res. 87, 69–78 (2009).

  100. 100

    Fulmer, C. G. et al. Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination. J. Neurosci. 34, 8186–8196 (2014).

  101. 101

    Xiao, J., Wong, A. W., Willingham, M. M. vanden Buuse, M., Kilpatrick, T. J. & Murray, S. S. Brain-derived neurotrophic factor promotes central nervous system myelination via a direct effect upon oligodendrocytes. Neurosignals 18, 186–202 (2010).

  102. 102

    Czopka, T., ffrench-Constant, C. & Lyons, D. A. Individual oligodendrocytes have only a few hours in which to generate new myelin sheaths in vivo. Dev. Cell. 25, 599–609 (2013).

  103. 103

    Kole, M. H. P. & Stuart, G. J. Signal processing in the axon initial segment. Neuron 73, 235–247 (2012).

  104. 104

    Kuba, H., Oichi, Y. & Ohmori, H. Presynaptic activity regulates Na+ channel distribution at the axon initial segment. Nature 465, 1075–1078 (2010).

  105. 105

    Grubb, M. S. & Burrone, J. Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability. Nature 465, 1070–1074 (2010).

  106. 106

    Tagoe, T., Barker, M., Jones, A., Allcock, N. & Hamann, M. Auditory nerve perinodal dysmyelination in noise-induced hearing loss. J. Neurosci. 34, 2684–2688 (2014).

  107. 107

    Fields, R. D. Myelin — more than insulation. Science 344, 264–266 (2014).

  108. 108

    Tomassy, G. S. et al. Distinct profiles of myelin distribution along single axons of pyramidal neurons in the neocortex. Science 334, 319–324 (2014).

  109. 109

    Schwab, M. E. & Strittmatter, S. M. Nogo limits neural plasticity and recovery from injury. Curr. Opin. Neurobiol. 27, 53–60 (2014).

  110. 110

    Bukalo, O. & Fields, R. D. Synaptic plasticity by antidromic firing during hippocampal network oscillations. Proc. Natl Acad. Sci. USA 110, 5175–5180 (2013).

  111. 111

    Bullock, T. H., Moore, J. K. & Fields, R. D. Evolution of myelin sheaths: both lamprey and hagfish lack myelin. Neurosci. Lett. 48, 145–148 (1984).

Download references

Acknowledgements

This work was supported by funds for intramural research from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Electron micrographs in Figure 2 are courtesy of Louis Dye, Microscopy Imaging Core, NICHD. 3D reconstruction is courtesy of Emily Benson and Grahame Kidd, Renovo, Inc.

Author information

Correspondence to R. Douglas Fields.

Ethics declarations

Competing interests

The author declares no competing financial interests.

PowerPoint slides

Glossary

Axolemma

The cell membrane of an axon.

Fractional anisotropy

(FA). A measure of the symmetry of water diffusion in tissue analysed by MRI. Increased FA reflects more restricted diffusion of water, as occurs when axons become myelinated or more highly compacted, thus restricting water diffusion parallel to the axons.

Non-synaptic transmission

Intercellular communication in the nervous system that does not involve synapses. This includes neurotransmitters released from vesicles fusing with the neuronal membrane outside synapses, as well as the release of neurotransmitters through membrane channels and other mechanisms.

Synaptic coupling

A specialized junction between cells in the nervous system for rapid communication by electrical signalling. Neurotransmitters released from synaptic vesicles in the presynaptic neuron in response to electrical depolarization activate neurotransmitter receptors on the membrane of the postsynaptic cell to depolarize or hyperpolarize the postsynaptic membrane potential.

Uncinate fasciculus

A white matter tract that connects the hippocampus, amygdala and temporal lobe with the orbitofrontal cortex of the brain.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Fields, R. A new mechanism of nervous system plasticity: activity-dependent myelination. Nat Rev Neurosci 16, 756–767 (2015) doi:10.1038/nrn4023

Download citation

Further reading