Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Regeneration and repair

Laws of attraction

Transplantation of neural precursor cells (NPCs) has promise as a cell-replacement therapy in neurodegenerative disorders; however, their efficacy is hampered by poor migration into, and population of, the host tissue. Here, the authors found that differentiating NPCs formed spherical clusters and secreted vascular endothelial growth factor and fibroblast growth factor 2, and that the secretion of these factors prevented the migration of the NPCs' neuronal progeny. Inhibition of these auto-attractive mechanisms enhanced the migration of grafted differentiating NPCs into rodent CNS tissue. Therefore, therapy based on these mechanisms might increase the effectiveness of neural transplants.


  1. Ladewig, J., Koch, P. & Brüstle, O. Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration. Nature Neurosci. (2013)

Download references


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lewis, S. Laws of attraction. Nat Rev Neurosci 15, 2 (2014).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing