et al. The effect of treatment expectation on drug efficacy: imaging the analgesic benefit of the opioid remifentanil. Sci. Transl. Med.
3, 70ra14 (2011).
Benedetti, F., Mayberg, H. S., Wager, T. D., Stohler, C. S. & Zubieta, J. K.
Neurobiological mechanisms of the placebo effect. J. Neurosci.
25, 10390–10402 (2005).
Villemure, C. & Bushnell, M. C.
Cognitive modulation of pain: how do attention and emotion influence pain processing?
95, 195–199 (2002).
Villemure, C. & Bushnell, M. C.
Mood influences supraspinal pain processing separately from attention. J. Neurosci.
29, 705–715 (2009). This is the first study to dissociate the circuitry involved in emotional and attentional modulation of pain.
Loggia, M. L., Mogil, J. S. & Bushnell, M. C.
Empathy hurts: compassion for another increases both sensory and affective components of pain perception. Pain
136, 168–176 (2008).
Schweinhardt, P. & Bushnell, M. C.
Pain imaging in health and disease — how far have we come?
J. Clin. Invest.
120, 3788–3797 (2010).
Hölzel, B. K.
et al. Mindfulness practice leads to increases in regional brain gray matter density. Psychiatry Res.
191, 36–43 (2011).
Grant, J. A., Courtemanche, J., Duerden, E. G., Duncan, G. H. & Rainville, P.
Cortical thickness and pain sensitivity in zen meditators. Emotion
10, 43–53 (2010).
Pagnoni, G. & Cekic, M.
Age effects on gray matter volume and attentional performance in Zen meditation. Neurobiol. Aging
28, 1623–1627 (2007).
Mackey, A. P., Whitaker, K. J. & Bunge, S. A.
Experience-dependent plasticity in white matter microstructure: reasoning training alters structural connectivity. Front. Neuroanat.
6, 32 (2012).
et al. Bridging the hemispheres in meditation: thicker callosal regions and enhanced fractional anisotropy (FA) in long-term practitioners. Neuroimage
61, 181–187 (2012).
Lutz, A., McFarlin, D. R., Perlman, D. M., Salomons, T. V. & Davidson, R. J.
Altered anterior insula activation during anticipation and experience of painful stimuli in expert meditators. Neuroimage
64, 538–546 (2013).
Apkarian, A. V., Bushnell, M. C., Treede, R. D. & Zubieta, J. K.
Human brain mechanisms of pain perception and regulation in health and disease. Eur. J. Pain
9, 463–484 (2005).
Friedman, D. P., Murray, E. A., O'Neill, J. B. & Mishkin, M.
Cortical connections of the somatosensory fields of the lateral sulcus of macaques: evidence for a corticolimbic pathway for touch. J. Comp. Neurol.
252, 323–347 (1986).
Rausell, E. & Jones, E. G.
Histochemical and immunocytochemical compartments of the thalamic VPM nucleus in monkeys and their relationship to the representational map. J. Neurosci.
11, 210–225 (1991).
Apkarian, A. V. & Shi, T. in Pain Mechanisms and Management (eds Ayrapetyan, S. N. & Apkarian, A. V.) 212–220 (IOS Press, 1998).
Craig, A. D. & Dostrovsky, J. O.
Thermoreceptive lamina I trigeminothalamic neurons project to the nucleus submedius in the cat. Exp. Brain Res.
85, 470–474 (1991).
Dum, R. P., Levinthal, D. J. & Strick, P. L.
The spinothalamic system targets motor and sensory areas in the cerebral cortex of monkeys. J. Neurosci.
29, 14223–14235 (2009). This is the first paper to show all of the cortical targets of the spinothalamic system.
Saab, C. Y. & Willis, W. D.
The cerebellum: organization, functions and its role in nociception. Brain Res. Brain Res. Rev.
42, 85–95 (2003).
Monconduit, L. & Villanueva, L.
The lateral ventromedial thalamic nucleus spreads nociceptive signals from the whole body surface to layer I of the frontal cortex. Eur. J. Neurosci.
21, 3395–3402 (2005).
Becerra, L., Breiter, H. C., Wise, R., Gonzalez, R. G. & Borsook, D.
Reward circuitry activation by noxious thermal stimuli. Neuron
32, 927–946 (2001).
Baliki, M. N., Geha, P. Y., Fields, H. L. & Apkarian, A. V.
Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain. Neuron
66, 149–160 (2010).
Bernard, J. F., Bester, H. & Besson, J. M.
Involvement of the spino-parabrachio -amygdaloid and -hypothalamic pathways in the autonomic and affective emotional aspects of pain. Prog. Brain Res.
107, 243–255 (1996).
et al. A comparison of visceral and somatic pain processing in the human brainstem using functional magnetic resonance imaging. J. Neurosci.
25, 7333–7341 (2005).
Basbaum, A. I. & Fields, H. L.
Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry. Annu. Rev. Neurosci.
7, 309–338 (1984).
Kenshalo, D. R. Jr & Isensee, O.
Responses of primate SI cortical neurons to noxious stimuli. J. Neurophysiol.
50, 1479–1496 (1983).
Kenshalo, D. R. Jr, Chudler, E. H., Anton, F. & Dubner, R.
SI nociceptive neurons participate in the encoding process by which monkeys perceive the intensity of noxious thermal stimulation. Brain Res.
454, 378–382 (1988).
Chudler, E. H., Anton, F., Dubner, R. & Kenshalo, D. R. Jr.
Responses of nociceptive SI neurons in monkeys and pain sensation in humans elicited by noxious thermal stimulation: effect of interstimulus interval. J. Neurophysiol.
63, 559–569 (1990).
Ploner, M., Freund, H. J. & Schnitzler, A.
Pain affect without pain sensation in a patient with a postcentral lesion. Pain
81, 211–214 (1999).
Greenspan, J. D., Lee, R. R. & Lenz, F. A.
Pain sensitivity alterations as a function of lesion location in the parasylvian cortex. Pain
81, 273–282 (1999).
Penfield, W. & Boldrey, E.
Somatic motor and sensory representation in the cerebral cortex of man as studied by electrical stimulation. Brain
60, 389–443 (1937).
MacLean, P. D.
Psychosomatic disease and the “visceral brain.” Recent developments bearing on the Papez theory of emotion. Psychosom. Med.
11, 338–353 (1949).
Foltz, E. L. & Lowell, E. W.
Pain “relief” by frontal cingulumotomy. J. Neurosurg.
19, 89–100 (1962).
Foltz, E. L. & White, L. E.
The role or rostral cingulumotomy in “pain” relief. Int. J. Neurol.
6, 353–373 (1968).
Corkin, S. & Hebben, N.
Subjective estimates of chronic pain before and after psychosurgery or treatment in a pain unit. Pain
1, S150 (1981).
Berthier, M., Starkstein, S. & Leiguarda, R.
Asymbolia for pain: a sensory-limbic disconnection syndrome. Ann. Neurol.
24, 41–49 (1988).
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B. & Bushnell, M. C.
Pain affect encoded in human anterior cingulate but not somatosensory cortex. Science
277, 968–971 (1997). This is the first study to demonstrate the separation of sensory and affective pain processing in the cerebral cortex.
Tolle, T. R.
et al. Region-specific encoding of sensory and affective components of pain in the human brain: a positron emission tomography correlation analysis. Ann. Neurol.
45, 40–47 (1999).
Zubieta, J. K.
et al. Regional μ opioid receptor regulation of sensory and affective dimensions of pain. Science
293, 311–315 (2001). This study provides the first demonstration of the relevance of forebrain opioid receptors to pain modulation.
et al. Representation of pain and somatic sensation in the human insula: a study of responses to direct electrical cortical stimulation. Cereb. Cortex
12, 376–385 (2002).
Craig, A. D.
Significance of the insula for the evolution of human awareness of feelings from the body. Ann. NY Acad. Sci.
1225, 72–82 (2011).
Baliki, M. N., Geha, P. Y. & Apkarian, A. V.
Parsing pain perception between nociceptive representation and magnitude estimation. J. Neurophysiol.
101, 875–887 (2009).
Lamm, C., Decety, J. & Singer, T.
Meta-analytic evidence for common and distinct neural networks associated with directly experienced pain and empathy for pain. Neuroimage
54, 2492–2502 (2011).
Cheng, Y., Chen, C., Lin, C. P., Chou, K. H. & Decety, J.
Love hurts: an fMRI study. Neuroimage
51, 923–929 (2010).
Langford, D. J.
et al. Social modulation of pain as evidence for empathy in mice. Science
312, 1967–1970 (2006).
Rosen, G., Willoch, F., Bartenstein, P., Berner, N. & Rosjo, S.
Neurophysiological processes underlying the phantom limb pain experience and the use of hypnosis in its clinical management: an intensive examination of two patients. Int. J. Clin. Exp. Hypn.
49, 38–55 (2001).
Porro, C. A.
et al. Does anticipation of pain affect cortical nociceptive systems?
22, 3206–3214 (2002).
et al. Direct activation of the ventral striatum in anticipation of aversive stimuli. Neuron
40, 1251–1257 (2003).
Hsieh, J. C., Stone-Elander, S. & Ingvar, M.
Anticipatory coping of pain expressed in the human anterior cingulate cortex: a positron emission tomography study. Neurosci. Lett.
262, 61–64 (1999).
et al. Dissociating pain from its anticipation in the human brain. Science
284, 1979–1981 (1999). This is the first study to examine the effect of pain anticipation on pain processing.
et al. Expectation of pain enhances responses to nonpainful somatosensory stimulation in the anterior cingulate cortex and parietal operculum/posterior insula: an event-related functional magnetic resonance imaging study. J. Neurosci.
20, 7438–7445 (2000).
et al. Dynamic assessment of the right lateral frontal cortex response to painful stimulation. Neuroimage
50, 1177–1187 (2010).
Fairhurst, M., Wiech, K., Dunckley, P. & Tracey, I.
Anticipatory brainstem activity predicts neural processing of pain in humans. Pain
128, 101–110 (2007).
Beecher, H. K.
Pain in men wounded in battle. Ann. Surg.
123, 96–105 (1946).
Efficacy and effectiveness of cognitive behaviour therapy for chronic pain: progress and some challenges. Pain
152, S99–S106 (2011).
Zeidan, F., Grant, J. A., Brown, C. A., McHaffie, J. G. & Coghill, R. C.
Mindfulness meditation-related pain relief: evidence for unique brain mechanisms in the regulation of pain. Neurosci. Lett.
520, 165–173 (2012).
Jensen, K. B.
et al. The use of functional neuroimaging to evaluate psychological and other non-pharmacological treatments for clinical pain. Neurosci. Lett.
520, 156–164 (2012).
Beydoun, A., Morrow, T. J., Shen, J. F. & Casey, K. L.
Variability of laser-evoked potentials: attention, arousal and lateralized differences. Electroencephalogr. Clin. Neurophysiol.
88, 173–181 (1993).
Roy, M., Peretz, I. & Rainville, P.
Emotional valence contributes to music-induced analgesia. Pain
134, 140–147 (2008).
Villemure, C., Slotnick, B. M. & Bushnell, M. C.
Effects of odors on pain perception: deciphering the roles of emotion and attention. Pain
106, 101–108 (2003).
Loggia, M. L., Mogil, J. S. & Bushnell, M. C.
Experimentally induced mood changes preferentially affect pain unpleasantness. J. Pain
9, 784–791 (2008).
Roy, M., Lebuis, A., Peretz, I. & Rainville, P.
The modulation of pain by attention and emotion: a dissociation of perceptual and spinal nociceptive processes. Eur. J. Pain
15, 641–610 (2011).
Bushnell, M. C.
et al. Pain perception: is there a role for primary somatosensory cortex?
Proc. Natl Acad. Sci. USA
96, 7705–7709 (1999).
Longe, S. E.
et al. Counter-stimulatory effects on pain perception and processing are significantly altered by attention: an fMRI study. Neuroreport
12, 2021–2025 (2001).
Bantick, S. J.
et al. Imaging how attention modulates pain in humans using functional MRI. Brain
125, 310–319 (2002).
Brooks, J. C., Nurmikko, T. J., Bimson, W. E., Singh, K. D. & Roberts, N.
fMRI of thermal pain: effects of stimulus laterality and attention. Neuroimage
15, 293–301 (2002).
et al. Distraction modulates connectivity of the cingulo–frontal cortex and the midbrain during pain — an fMRI analysis. Pain
109, 399–408 (2004).
et al. Modulation of pain processing in hyperalgesia by cognitive demand. Neuroimage
27, 59–69 (2005).
Ploner, M., Lee, M. C., Wiech, K., Bingel, U. & Tracey, I.
Flexible cerebral connectivity patterns subserve contextual modulations of pain. Cereb. Cortex
21, 719–726 (2011).
et al. Attentional modulation of visceral and somatic pain. Neurogastroenterol. Motil.
19, 569–577 (2007).
Phillips, M. L.
et al. The effect of negative emotional context on neural and behavioural responses to oesophageal stimulation. Brain
126, 669–684 (2003).
Roy, M., Piche, M., Chen, J. I., Peretz, I. & Rainville, P.
Cerebral and spinal modulation of pain by emotions. Proc. Natl Acad. Sci. USA
106, 20900–20905 (2009).
et al. Induction of depressed mood disrupts emotion regulation neurocircuitry and enhances pain unpleasantness. Biol. Psychiatry
Basbaum, A. I. & Fields, H. L.
Endogenous pain control mechanisms: review and hypothesis. Ann. Neurol.
4, 451–462 (1978). This article provides the first complete analysis of descending pain modulatory circuits.
Ossipov, M. H., Dussor, G. O. & Porreca, F.
Central modulation of pain. J. Clin. Invest.
120, 3779–3787 (2010).
Petrovic, P., Petersson, K. M., Ghatan, P. H., Stone-Elander, S. & Ingvar, M.
Pain-related cerebral activation is altered by a distracting cognitive task. Pain
85, 19–30 (2000).
Frankenstein, U. N., Richter, W., McIntyre, M. C. & Remy, F.
Distraction modulates anterior cingulate gyrus activations during the cold pressor test. Neuroimage
14, 827–836 (2001).
et al. Imaging attentional modulation of pain in the periaqueductal gray in humans. J. Neurosci.
22, 2748–2752 (2002).
Corbetta, M. & Shulman, G. L.
Control of goal-directed and stimulus-driven attention in the brain. Nature Rev. Neurosci.
3, 201–215 (2002).
Cavada, C. & Goldman-Rakic, P. S.
Posterior parietal cortex in rhesus monkey: I. Parcellation of areas based on distinctive limbic and sensory corticocortical connections. J. Comp. Neurol.
287, 393–421 (1989).
Cavada, C. & Goldman-Rakic, P. S.
Posterior parietal cortex in rhesus monkey: II. Evidence for segregated corticocortical networks linking sensory and limbic areas with the frontal lobe. J. Comp. Neurol.
287, 422–445 (1989).
Prevosto, V., Graf, W. & Ugolini, G.
Proprioceptive pathways to posterior parietal areas MIP and LIPv from the dorsal column nuclei and the postcentral somatosensory cortex. Eur. J. Neurosci.
33, 444–460 (2011).
et al. Activation of the opioidergic descending pain control system underlies placebo analgesia. Neuron
63, 533–543 (2009).
Wager, T. D.
et al. Placebo-induced changes in fMRI in the anticipation and experience of pain. Science
303, 1162–1167 (2004). This study identifies the neural circuitry underlying placebo analgesia.
Wager, T. D., Scott, D. J. & Zubieta, J. K.
Placebo effects on human μ-opioid activity during pain. Proc. Natl Acad. Sci. USA
104, 11056–11061 (2007).
Amanzio, M. & Benedetti, F.
Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated specific subsystems. J. Neurosci.
19, 484–494 (1999).
Zhang, R.-R., Zhang, W.-C., Wang, J.-Y. & Guo, J.-Y.
The opioid placebo analgesia is mediated exclusively through μ-opioid receptor in rat. Int. J. Neuropsychopharmacol.
16, 849–856 (2013).
Guo, J. Y., Wang, J. Y. & Luo, F.
Dissection of placebo analgesia in mice: the conditions for activation of opioid and non-opioid systems. J. Psychopharmacol.
24, 1561–1567 (2010).
Buhle, J. T., Stevens, B. L., Friedman, J. J. & Wager, T. D.
Distraction and placebo: two separate routes to pain control. Psychol. Sci.
23, 246–253 (2012).
Derbyshire, S. W.
et al. Cerebral responses to noxious thermal stimulation in chronic low back pain patients and normal controls. Neuroimage
16, 158–168 (2002).
Gracely, R. H., Petzke, F., Wolf, J. M. & Clauw, D. J.
Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum.
46, 1333–1343 (2002). This paper demonstrates enhanced pain processing in patients with chronic pain.
Lawal, A., Kern, M., Sidhu, H., Hofmann, C. & Shaker, R.
Novel evidence for hypersensitivity of visceral sensory neural circuitry in irritable bowel syndrome patients. Gastroenterology
130, 26–33 (2006).
Naliboff, B. D.
et al. Cerebral activation in patients with irritable bowel syndrome and control subjects during rectosigmoid stimulation. Psychosom. Med.
63, 365–375 (2001).
Pukall, C. F.
et al. Neural correlates of painful genital touch in women with vulvar vestibulitis syndrome. Pain
115, 118–127 (2005).
Gwilym, S. E.
et al. Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients. Arthritis Rheum.
61, 1226–1234 (2009).
Porreca, F., Ossipov, M. H. & Gebhart, G. F.
Chronic pain and medullary descending facilitation. Trends Neurosci.
25, 319–325 (2002).
Le Bars, D.
The whole body receptive field of dorsal horn multireceptive neurones. Brain Res. Brain Res. Rev.
40, 29–44 (2002).
Sprenger, C., Bingel, U. & Buchel, C.
Treating pain with pain: supraspinal mechanisms of endogenous analgesia elicited by heterotopic noxious conditioning stimulation. Pain
152, 428–439 (2011).
Lewis, G. N., Rice, D. A. & McNair, P. J.
Conditioned pain modulation in populations with chronic pain: a systematic review and meta-analysis. J. Pain
13, 936–944 (2012).
Jensen, K. B.
et al. Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain. Pain
144, 95–100 (2009).
et al. Fibromyalgia unique temporal brain activation during experimental pain: a controlled fMRI study. J. Neural Transm.
117, 123–131 (2010).
Berman, S. M.
et al. Reduced brainstem inhibition during anticipated pelvic visceral pain correlates with enhanced brain response to the visceral stimulus in women with irritable bowel syndrome. J. Neurosci.
28, 349–359 (2008).
Baliki, M. N.
et al. Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain. J. Neurosci.
26, 12165–12173 (2006). This study shows that chronic pain activates unique patterns of cortical activity.
Seminowicz, D. A.
et al. Effective treatment of chronic low back pain in humans reverses abnormal brain anatomy and function. J. Neurosci.
31, 7540–7550 (2011).
et al. Affective components and intensity of pain correlate with structural differences in gray matter in chronic back pain patients. Pain
125, 89–97 (2006).
Apkarian, A. V.
et al. Chronic back pain is associated with decreased prefrontal and thalamic gray matter density. J. Neurosci.
24, 10410–10415 (2004).
Davis, K. D. & Moayedi, M.
Central mechanisms of pain revealed through functional and structural MRI. J. Neuroimmune Pharmacol.
24 Jul 2012 (doi:10.1007/s11481-012-9386-8).
Geha, P. Y.
et al. The brain in chronic CRPS pain: abnormal gray–white matter interactions in emotional and autonomic regions. Neuron
60, 570–581 (2008). This study links chronic pain with both grey and white matter changes.
et al. White and gray matter abnormalities in the brain of patients with fibromyalgia: a diffusion-tensor and volumetric imaging study. Arthritis Rheum.
58, 3960–3969 (2008).
Sundgren, P. C.
et al. Diffusion-weighted and diffusion tensor imaging in fibromyalgia patients: a prospective study of whole brain diffusivity, apparent diffusion coefficient, and fraction anisotropy in different regions of the brain and correlation with symptom severity. Acad. Radiol.
14, 839–846 (2007).
Gerstner, G., Ichesco, E., Quintero, A. & Schmidt-Wilcke, T.
Changes in regional gray and white matter volume in patients with myofascial-type temporomandibular disorders: a voxel-based morphometry study. J. Orofac. Pain
25, 99–106 (2011).
Granziera, C., DaSilva, A. F., Snyder, J., Tuch, D. S. & Hadjikhani, N.
Anatomical alterations of the visual motion processing network in migraine with and without aura. PLoS. Med.
3, e402 (2006).
et al. White matter microstructural alterations in migraine: a diffusion-weighted MRI study. Pain
153, 651–656 (2012).
et al. White matter brain and trigeminal nerve abnormalities in temporomandibular disorder. Pain
153, 1467–1477 (2012).
McEwen, B. S.
The neurobiology of stress: from serendipity to clinical relevance. Brain Res.
886, 172–189 (2000).
Apkarian, A. V.
et al. Expression of IL-1β in supraspinal brain regions in rats with neuropathic pain. Neurosci. Lett.
407, 176–181 (2006).
Norman, G. J.
et al. Stress and IL-1β contribute to the development of depressive-like behavior following peripheral nerve injury. Mol. Psychiatry
15, 404–414 (2010).
et al. Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex. J. Neurosci.
28, 7445–7453 (2008).
Metz, A. E., Yau, H. J., Centeno, M. V., Apkarian, A. V. & Martina, M.
Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain. Proc. Natl Acad. Sci. USA
106, 2423–2428 (2009).
Grachev, I. D., Fredrickson, B. E. & Apkarian, A. V.
Brain chemistry reflects dual states of pain and anxiety in chronic low back pain. J. Neural Transm.
109, 1309–1334 (2002).
Harris, R. E.
et al. Dynamic levels of glutamate within the insula are associated with improvements in multiple pain domains in fibromyalgia. Arthritis Rheum.
58, 903–907 (2008).
Grachev, I. D., Fredrickson, B. E. & Apkarian, A. V.
Abnormal brain chemistry in chronic back pain: an in vivo proton magnetic resonance spectroscopy study. Pain
89, 7–18 (2000).
Harris, R. E.
et al. Elevated insular glutamate in fibromyalgia is associated with experimental pain. Arthritis Rheum.
60, 3146–3152 (2009).
Gussew, A., Rzanny, R., Gullmar, D., Scholle, H. C. & Reichenbach, J. R.
1H-MR spectroscopic detection of metabolic changes in pain processing brain regions in the presence of non-specific chronic low back pain. Neuroimage
54, 1315–1323 (2011).
Mhalla, A., de Andrade, D. C., Baudic, S., Perrot, S. & Bouhassira, D.
Alteration of cortical excitability in patients with fibromyalgia. Pain
149, 495–500 (2010).
Harris, R. E.
et al. Decreased central μ-opioid receptor availability in fibromyalgia. J. Neurosci.
27, 10000–10006 (2007).
Jones, A. K. P.
et al. Changes in central opioid receptor binding in relation to inflammation and pain in patients with rheumatoid arthritis. Br. J. Rheumatol.
33, 909–916 (1994).
Jones, A. K., Watabe, H., Cunningham, V. J. & Jones, T.
Cerebral decreases in opioid receptor binding in patients with central neuropathic pain measured by [11C]diprenorphine binding and PET. Eur. J. Pain
8, 479–485 (2004).
et al. Differential brain opioid receptor availability in central and peripheral neuropathic pain. Pain
127, 183–194 (2007).
Wood, P. B.
et al. Fibromyalgia patients show an abnormal dopamine response to pain. Eur. J. Neurosci.
25, 3576–3582 (2007).
et al. Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala. Neuropsychopharmacology
31, 739–750 (2006).
et al. Chronic pain-induced emotional dysfunction is associated with astrogliosis due to cortical δ-opioid receptor dysfunction. J. Neurochem.
97, 1369–1378 (2006).
Moriarty, O., McGuire, B. E. & Finn, D. P.
The effect of pain on cognitive function: a review of clinical and preclinical research. Prog. Neurobiol.
93, 385–404 (2011).
Leavitt, F. & Katz, R. S.
Distraction as a key determinant of impaired memory in patients with fibromyalgia. J. Rheumatol.
33, 127–132 (2006).
Dick, B. D., Verrier, M. J., Harker, K. T. & Rashiq, S.
Disruption of cognitive function in Fibromyalgia Syndrome. Pain
139, 610–616 (2008).
Munguia-Izquierdo, D. & Legaz-Arrese, A.
Assessment of the effects of aquatic therapy on global symptomatology in patients with fibromyalgia syndrome: a randomized controlled trial. Arch. Phys. Med. Rehabil.
89, 2250–2257 (2008).
Verdejo-Garcia, A., Lopez-Torrecillas, F., Calandre, E. P., Delgado-Rodriguez, A. & Bechara, A.
Executive function and decision-making in women with fibromyalgia. Arch. Clin. Neuropsychol.
24, 113–122 (2009).
et al. Altered associative learning and emotional decision making in fibromyalgia. J. Psychosom. Res.
70, 294–301 (2011).
Apkarian, A. V.
et al. Chronic pain patients are impaired on an emotional decision-making task. Pain
108, 129–136 (2004).
Pais-Vieira, M., Mendes-Pinto, M. M., Lima, D. & Galhardo, V.
Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain. Neuroscience
161, 671–679 (2009).
et al. Differential SPECT activation patterns associated with PASAT performance may indicate frontocerebellar functional dissociation in chronic mild traumatic brain injury. J. Nucl. Med.
50, 1054–1061 (2009).
Yu, H. J.
et al. Multiple white matter tract abnormalities underlie cognitive impairment in RRMS. Neuroimage
59, 3713–3722 (2012).
Sigurdardottir, S., Jerstad, T., Andelic, N., Roe, C. & Schanke, A. K.
Olfactory dysfunction, gambling task performance and intracranial lesions after traumatic brain injury. Neuropsychology
24, 504–513 (2010).
van Noordt, S. & Good, D.
Mild head injury and sympathetic arousal: investigating relationships with decision-making and neuropsychological performance in university students. Brain Inj.
25, 707–716 (2011).
et al. Cognitive deficits in multiple sclerosis correlate with changes in fronto-subcortical tracts. Mult. Scler.
14, 364–369 (2008).
Owen, A. M., McMillan, K. M., Laird, A. R. & Bullmore, E.
N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies. Hum. Brain Mapp.
25, 46–59 (2005).
Bechara, A., Damasio, H. & Damasio, A. R.
Emotion, decision making and the orbitofrontal cortex. Cereb. Cortex
10, 295–307 (2000).
et al. Patients with irritable bowel syndrome have altered emotional modulation of neural responses to visceral stimuli. Gastroenterology
139, 1310–1319 (2010).
et al. Behavioral and neuronal investigations of hypervigilance in patients with fibromyalgia syndrome. PLoS ONE
7, e35068 (2012).
Arnold, B. S.
et al. Affective pain modulation in fibromyalgia, somatoform pain disorder, back pain, and healthy controls. Eur. J. Pain
12, 329–338 (2008).
Snijders, T. J., Ramsey, N. F., Koerselman, F. & van Gijn, J.
Attentional modulation fails to attenuate the subjective pain experience in chronic, unexplained pain. Eur. J. Pain
14, 282.e1–282.e10 (2010).
Montoya, P., Pauli, P., Batra, A. & Wiedemann, G.
Altered processing of pain-related information in patients with fibromyalgia. Eur. J. Pain
9, 293–303 (2005).
Vase, L., Robinson, M. E., Verne, G. N. & Price, D. D.
Increased placebo analgesia over time in irritable bowel syndrome (IBS) patients is associated with desire and expectation but not endogenous opioid mechanisms. Pain
115, 338–347 (2005).
et al. Gray matter changes related to chronic posttraumatic headache. Neurology
73, 978–983 (2009).
Rodriguez-Raecke, R., Niemeier, A., Ihle, K., Ruether, W. & May, A.
Brain gray matter decrease in chronic pain is the consequence and not the cause of pain. J. Neurosci.
29, 13746–13750 (2009).
Gwilym, S. E., Filippini, N., Douaud, G., Carr, A. J. & Tracey, I.
Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study. Arthritis Rheum.
62, 2930–2940 (2010).
Zhao, M. G., Toyoda, H., Wang, Y. K. & Zhuo, M.
Enhanced synaptic long-term potentiation in the anterior cingulate cortex of adult wild mice as compared with that in laboratory mice. Mol. Brain
2, 11 (2009).
Ikeda, H., Tsuda, M., Inoue, K. & Murase, K.
Long-term potentiation of neuronal excitation by neuron-glia interactions in the rat spinal dorsal horn. Eur. J. Neurosci.
25, 1297–1306 (2007).
Jensen, K. B.
et al. Cognitive Behavioral Therapy increases pain-evoked activation of the prefrontal cortex in patients with fibromyalgia. Pain
153, 1495–1503 (2012).
Grant, J. A., Courtemanche, J. & Rainville, P.
A non-elaborative mental stance and decoupling of executive and pain-related cortices predicts low pain sensitivity in Zen meditators. Pain
152, 150–156 (2011).
et al. Pain attenuation through mindfulness is associated with decreased cognitive control and increased sensory processing in the brain. Cereb. Cortex
22, 2692–2702 (2012).
et al. Brain mechanisms supporting the modulation of pain by mindfulness meditation. J. Neurosci.
31, 5540–5548 (2011).
Lazar, S. W.
et al. Meditation experience is associated with increased cortical thickness. Neuroreport
16, 1893–1897 (2005).
Holzel, B. K.
et al. Investigation of mindfulness meditation practitioners with voxel-based morphometry. Soc. Cogn. Affect. Neurosci.
3, 55–61 (2008).
Luders, E., Toga, A. W., Lepore, N. & Gaser, C.
The underlying anatomical correlates of long-term meditation: larger hippocampal and frontal volumes of gray matter. Neuroimage
45, 672–678 (2009).
On the relationship between emotion and cognition. Nature Rev. Neurosci.
9, 148–158 (2008).
Seminowicz, D. A.
et al. MRI structural brain changes associated with sensory and emotional function in a rat model of long-term neuropathic pain. Neuroimage
47, 1007–1014 (2009).
Low, L. A.
et al. Nerve injury causes long-term attentional deficits in rats. Neurosci. Lett.
529, 103–107 (2012).
deCharms, R. C.
et al. Control over brain activation and pain learned by using real-time functional MRI. Proc. Natl Acad. Sci. USA
102, 18626–18631 (2005).
Yoo, S. S.
et al. Brain–computer interface using fMRI: spatial navigation by thoughts. Neuroreport
15, 1591–1595 (2004).
van Praag, H., Kempermann, G. & Gage, F. H.
Neural consequences of enviromental enrichment. Nature Rev. Neurosci.
1, 191–198 (2000).
Gabriel, A. F.
et al. Enriched environment and the recovery from inflammatory pain: social versus physical aspects and their interaction. Behav. Brain Res.
208, 90–95 (2010).
Gabriel, A. F., Marcus, M. A. E., Honig, W. M. M. & Joosten, E. A. J.
Preoperative housing in an enriched environment significantly reduces the duration of post-operative pain in a rat model of knee inflammation. Neurosci. Lett.
469, 219–223 (2010).
Gabriel, A. F., Marcus, M. A., Honig, W. M., Helgers, N. & Joosten, E. A.
Environmental housing affects the duration of mechanical allodynia and the spinal astroglial activation in a rat model of chronic inflammatory pain. Brain Res.
1276, 83–90 (2009).
Abramov, U., Kurrikoff, K., Matsui, T. & Vasar, E.
Environmental enrichment reduces mechanical hypersensitivity in neuropathic mice, but fails to abolish the phenotype of CCK2 receptor deficient mice. Neurosci. Lett.
467, 230–233 (2009).
Shum, F. W.
et al. Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment. Learn. Mem.
14, 304–312 (2007).
Stagg, N. J.
et al. Regular exercise reverses sensory hypersensitivity in a rat neuropathic pain model: role of endogenous opioids. Anesthesiology
114, 940–948 (2011).
et al. Oxytocin levels in the posterior pituitary and in the heart are modified by voluntary wheel running. Regul. Pept.
139, 96–101 (2007).
Boyette-Davis, J. A., Thompson, C. D. & Fuchs, P. N.
Alterations in attentional mechanisms in response to acute inflammatory pain and morphine administration. Neuroscience
151, 558–563 (2008).
Ford, G. K., Moriarty, O., McGuire, B. E. & Finn, D. P.
Investigating the effects of distracting stimuli on nociceptive behaviour and associated alterations in brain monoamines in rats. Eur. J. Pain
12, 970–979 (2008).
et al. Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation. J. Neurosci.
30, 5451–5464 (2010).
et al. The impact of age on emotional and cognitive behaviours triggered by experimental neuropathy in rats. Pain
144, 57–65 (2009).
Hu, Y., Yang, J., Hu, Y., Wang, Y. & Li, W.
Amitriptyline rather than lornoxicam ameliorates neuropathic pain-induced deficits in abilities of spatial learning and memory. Eur. J. Anaesthesiol.
27, 162–168 (2010).