Thirty years have passed since the publication of Elie Bienenstock, Leon Cooper and Paul Munro's 'Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex', known as the BCM theory of synaptic plasticity. This theory has guided experimentalists to discover some fundamental properties of synaptic plasticity and has provided a mathematical structure that bridges molecular mechanisms and systems-level consequences of learning and memory storage.
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The authors thank the many colleagues, both theoretical and experimental, with whom they have worked these many years. Our collaborative research has been supported by the US Office of Naval Research, the Army Research Office, the Air Force Office of Scientific Research, the National Science Foundation, the US National Institutes of Health, the Howard Hughes Medical Institute, the Dana Foundation and the Ittleson Family Foundation.
The authors declare no competing financial interests.
The Institute for Brain and Neural Systems, Brown University
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Cooper, L., Bear, M. The BCM theory of synapse modification at 30: interaction of theory with experiment. Nat Rev Neurosci 13, 798–810 (2012). https://doi.org/10.1038/nrn3353
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