This month, we are delighted to be celebrating the tenth anniversary of Nature Reviews Neuroscience. To mark the occasion, we asked the authors of each year's most cited article in the journal to reflect on their field of research at the time their article was published, to discuss the impact of their article on the field and to identify the questions that may be answered in the next 10 years. Their contributions can be found in the Viewpoint on page 718.

This issue also includes interviews with James Rothman, Richard Scheller and Thomas Südhof, who were awarded the Kavli Prize in Neuroscience for their research into, and formulation of, the SNARE hypothesis of intracellular membrane fusion (page 669).

Stress continues to fascinate basic and clinical neuroscientists alike. On page 710, Lightman and Conway-Campbell show that glucocorticoid 'stress hormones' are released in a pulsatile fashion and discuss the relevance of this for glucocorticoid signalling in the brain — a topic that could have important clinical implications given the widespread therapeutic use of these hormones. In a Progress article on page 675, Krugers, Hoogenraad and Groc discuss how glucocorticoids can promote the acquisition and consolidation of memories of stressful events by modulating AMPA receptor function.

In the 10 years since its launch, Nature Reviews Neuroscience has aimed to publish timely, authoritative and thought-provoking Review and Perspective articles covering all areas of neuroscience. The success of the journal is in large part due to the quality of the authors and referees, whom we thank for their continuing support. As we enter our second decade, we look forward to further fruitful collaborations with leading researchers in neuroscience.