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Understanding microRNAs in neurodegeneration

Nature Reviews Neuroscience volume 10, pages 837–841 (2009)Cite this article

Abstract

Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. Investigations have begun to reveal the influence of miRNAs on both neuronal survival and the accumulation of toxic proteins that are associated with neurodegeneration, and are providing clues as to how these toxic proteins can influence miRNA expression.

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Figure 1: mRNA repression by microRNAs and their effect on neurodegeneration.

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Acknowledgements

We apologize to authors whose papers were not discussed here owing to the short format. This work was funded by United States Public Health Service grant DA00266. T.M.D. is the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases at the Johns Hopkins University School of Medicine.

Author information

Authors and Affiliations

  1. the Institute for Cell Engineering and the Department of Neurology at the Johns Hopkins University School of Medicine, Stephen M. Eacker, Ted M. Dawson and Valina L. Dawson are at the Neuroregeneration and Stem Cell Programs, Baltimore, Maryland 21205, USA.,

    Stephen M. Eacker, Ted M. Dawson & Valina L. Dawson

  2. Ted M. Dawson and Valina L. Dawson are also at the Department of Neuroscience at the Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.,

    Ted M. Dawson & Valina L. Dawson

  3. Valina L. Dawson is also at the Department of Physiology at the Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.,

    Valina L. Dawson

Authors
  1. Stephen M. Eacker
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  2. Ted M. Dawson
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  3. Valina L. Dawson
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Corresponding authors

Correspondence to Ted M. Dawson or Valina L. Dawson.

Related links

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DATABASES

mirBase

mir-9

miR-124

miR-132

miR-133b

miR-433

miR-659

OMIM

FTLD

FURTHER INFORMATION

Ted M. Dawson's homepage

Valina L. Dawson's homepage

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Eacker, S., Dawson, T. & Dawson, V. Understanding microRNAs in neurodegeneration. Nat Rev Neurosci 10, 837–841 (2009). https://doi.org/10.1038/nrn2726

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