Neuroscientists associate the name of Donald O. Hebb with the Hebbian synapse and the Hebbian learning rule, which underlie connectionist theories and synaptic plasticity, but Hebb's work has also influenced developmental psychology, neuropsychology, perception and the study of emotions, as well as learning and memory. Here, we review the work of Hebb and its lasting influence on neuroscience in honour of the 2004 centenary of his birth.
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Hebb, D. O. The Organization of Behavior; a Neuropsychological Theory (Wiley, New York, 1949) (reprinted by Lawrence Erlbaum Associates, 2002).
Seung, H. S. Half a century of Hebb. Nature Neurosci. 3, Suppl. 1166 (2000).
Fentress, J. C. The Organization of Behavior revisited. Can. J. Exp. Psychol. 53, 8–20 (1999).
Harnad, S. D. O. Hebb: father of cognitive psychobiology: 1904–1985. Behav. Brain Sci. 8, 529 (1985).
Fentress, J. C. D. O. Hebb and the developmental organization of behavior. Dev. Psychobiol. 20, 103–109 (1987).
Klein, R. M. The Hebb legacy. Can. J. Exp. Psychol. 53, 1–3 (1999).
Milner, P. M. The mind and Donald O. Hebb. Sci. Am. 268, 124–129 (1993).
Hebb, D. O. D. O. Hebb . in A History of Psychology in Autobiography Vol. VII (ed. G. Lindzey) 273–309 (W. H. Freeman, San Francisco, 1980).
Hebb, D. O. Elementary school methods. Teacher's magazine 12, 23–26 (1930).
Sherrington, C. The Integrative Action of the Nervous System (Yale Univ. Press, New Haven, 1906).
Pavlov, I. P. Conditioned Reflexes (Dover Publications, New York, 1927).
Hebb, D. O. Conditioned and Unconditioned Reflexes and Inhibition. M.A. Thesis, McGill Univ. (1932).
Hebb, D. O. Essay on Mind (Erlbaum, Hillsdale, New Jersey,1980).
Dewsbury, D. A. The Chicago five: a family group of integrative psychobiologists. Hist. Psychol. 5, 16–37 (2002).
Hebb, D. O. The innate organization of visual activity: I. Perception of figures by rats reared in total darkness. J. Gen. Psychol. 51, 101–126 (1937).
Hebb, D. O. Studies of the organization of behavior. I. Behavior of the rat in a field orientation. J. Comp. Psychol. 25, 333–353 (1938).
Hebb, D. O. Intelligence in man after large removals of cerebral tissue: report of four left frontal lobe cases. J. Gen. Psychol. 21, 73–87 (1939).
Hebb, D. O. & Morton, N. W. Note on the measurement of adult intelligence. J. Gen. Psychol. 30, 217–223 (1944).
Hebb, D. O. Intelligence in man after large removals of cerebral tissue: defects following right temporal lobotomy. J. Gen. Psychol. 21, 437–446 (1939).
Hebb, D. O. & Morton, N. W. The McGill adult comprehension examination: verbal situation and picture anomaly series. J. Educ. Psychol. 34, 16–25 (1943).
Hebb, D. O. & Penfield, W. Human behavior after extensive bilateral removal from the frontal lobes. Arch. Neurol. Psychiatry 42, 421–438 (1940).
Hebb, D. O. Man's frontal lobes: a critical review. Arch. Neurol. Psychiatry 54, 10–24 (1945).
Rosvold, H. E. & Mishkin, M. Evaluation of the effects of prefrontal lobotomy on intelligence. Can. J. Psychol. 4, 122–126 (1950).
Milner, B. Intellectual function of the temporal lobes. Psychol. Bull. 51, 42–62 (1954).
Scoville, W. B. & Milner, B. Loss of recent memory after bilateral hippocampal lesions. J. Neurochem. 20, 11–21 (1957).
Hebb, D. O. & Williams, K. A method of rating animal intelligence. J. Gen. Psychol. 34, 59–65 (1946).
Brown, R. E. and Stanford, L. The Hebb–Williams Maze: 50 years of research (1946–1996). Soc. Neurosc. Abstr. 23, 110.14 (1997).
Hebb, D. O. The effects of early experience on problem solving at maturity. Am. Psychol. 2, 306–307 (1947).
Mann, E. T., Elliot, C. C. Assessment of the utility of project Head Start for the culturally deprived: an evaluation of social and psychological functioning. Train. Sch. Bull. (Vinel). 64, 119–125 (1968).
Wiesel, T. N & Hubel, D. H. Comparison of the effects of unilateral and bilateral eye closure on cortical unit responses in the kitten. J. Neurophysiol. 28, 1029–1040 (1965).
Hebb, D. O. The effects of early and late brain injury upon test scores, and the nature of normal adult intelligence. Proc. Am. Phil. Soc. 85, 275–292 (1942).
Hebb, D. O. Emotion in man and animal: an analysis of the intuitive processes of recognition. Psychol. Rev. 53, 88–106 (1946).
Hebb, D. O. On the nature of fear. Psychol. Rev. 53, 259–276 (1946).
McBride, A. F. & Hebb, D. O. Behavior of the captive bottle-nose dolphin, Tursiops truncatus. J. Comp. Physiol. Psychol. 41, 111–123 (1948).
Berger, H. Über das Elektrenkephalogramm des Menchen. Archiv Für Psychiatrie und Nervenkrankheiten (Berlin) 87, 527–570 (1929).
Hull, C. L. Principles of Behavior: An Introduction to Behavior Theory (Appleton-Century, New York, 1943).
Lashley, K. S. Brain Mechanisms and Intelligence: a Quantitative Study of Injuries to the Brain (Univ. Chicago Press, Chicago, 1929).
Hebb, D. O. A Textbook of Psychology (Saunders, Philadelphia, 1958).
Hebb, D. O. Education for research. Can. Fed. News 8, 53–57 (1966).
Hebb, D. O. What psychology is about. Am. Psychol. 29, 71–79 (1974).
Heron, W. The pathology of boredom. Sci. Am. 196, 52–56 (1957).
Hebb, D. O. Drives and the C.N.S. (conceptual nervous system). Psychol. Rev. 62, 243–254 (1955).
Hebb, D. O. & Thompson, W. R. in Handbook of Social Psychology Vol. 1 (ed. G. Lindzey) 532–561 (Addison-Wesley, Cambridge, Massachusetts, 1954).
Sejnowski, T. J. The book of Hebb. Neuron 24, 773–776 (1999).
Bi, G. & Poo, M. Synaptic modification by correlated activity: Hebb's postulate revisited. Annu. Rev. Neurosci. 24, 139–166 (2001).
Haggbloom, S. J., Warnick, R., Warnick, J. E. The 100 most eminent psychologists of the 20th century. Rev. Gen. Psychol. 6, 139–152 (2002).
Martinez, J. L., Jr. and Glickman, S. E. Hebb revisited: perception, plasticity, and the Hebb synapse. Contemp. Psychol. 39, 1018–1020 (1994).
Nicolelis, M. A., Fanselow, E. E., Ghazanfar, A. A. Hebb's dream: the resurgence of cell assemblies. Neuron 19, 219–221 (1997).
Spatz H. C. Hebb's concept of synaptic plasticity and neuronal cell assemblies. Behav. Brain Res. 78, 3–7 (1996).
Milner, P. A brief history of the Hebbian learning rule. Can. Psychol. 44, 5 (2003).
Hinton, G. The ups and downs of Hebb synapses. Can. Psychol. 44, 10 (2003).
Kolb, B. The impact of the Hebbian learning rule on research in behavioural neuroscience. Can. Psychol. 44, 14 (2003).
Sejnowski, T. J. The once and future of Hebb synapse. Can. Psychol. 44, 17 (2003).
Adams, P. Hebb and Darwin. J. Theor. Biol. 195, 419–438 (1998).
Stent, G. S. A physiological mechanism for Hebb's postulate of learning. Proc. Natl Acad. Sci. USA 70, 997–1001 (1973).
Kupfermann, I. & Pinsker, H. in Biology of Memory (eds K. H. Pribram & D. E. Broadbent) 163–174 (Academic Press, New York, 1970).
Rauschecker, J. P. & Singer, W. The effects of early experience on the cat's visual cortex and their possible explanation by Hebb synapses. J. Physiol. (Lond.) 310, 215–239 (1981).
Kappers, A. Three Lectures on Neurobiotaxis (Heinemann, London, 1928).
Sherrington, C. S. Remarks on some aspects of reflex inhibition. Proc. R. Soc. Lond. B 97, 519–545 (1925).
Bliss, T. V. & Lomo, T. Plasticity in a monosynaptic cortical pathway. J. Physiol. (Lond.) 207, 61P (1973).
Lin, X. Y. & Glanzman, D. L. Hebbian induction of long-term potentiation of Aplysia sensorimotor synapses: partial requirement for activation of an NMDA-related receptor. Proc. R. Soc. Lond. B 255, 113–118 (1994).
We would like to thank the McGill University archives for access to Hebb's files, and Mary Ellen Hebb and Jane Hebb Paul for access to family photographs and letters.
The authors declare no competing financial interests.
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Brown, R., Milner, P. The legacy of Donald O. Hebb: more than the Hebb Synapse. Nat Rev Neurosci 4, 1013–1019 (2003). https://doi.org/10.1038/nrn1257
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