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This paper provided the complete amino acid sequence of BuChE.
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A modelling study of the structure of BuChE.
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A thorough review of the diverse molecular forms of cholinesterase, including BuChE.
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Direct proof of the relevance of the association of BuChE with proteases in terms of enhancing proteolytic activity.
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An inhibitor-based investigation showing that the cholinesterase activity that is found in plaques and tangles in AD is aryl acylamidase activity.
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One of two studies showing a correlation between BuChE inhibition and cognitive improvement in AD.
Farlow, M., Anand, R., Messina, J. Jr, Hartman, R. & Veach, J. A 52-week study of the efficacy of rivastigmine in patients with mild to moderately severe Alzheimer's disease. Eur. Neurol. 44, 236–241 (2000).
Corey-Bloom, J. et al. A randomised trial evaluating the efficacy and safety of ENA 713 (rivastigmine tartrate), a new acetylcholinesterase inhibitor, in patients with mild to moderate severe Alzheimer's disease. Int. J. Geriatr. Psychiatry 1, 55–65 (1998).
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A study showing that cholinesterase inhibitors reduce the levels of APP and the Aβ-peptide, which is deposited in plaques in AD.
Shaw, K. T. et al. Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc. Natl Acad. Sci. USA 98, 7605–7610 (2001).
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