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Incorporating sex as a biological variable in neuroscience: what do we gain?

New policies requiring preclinical studies to incorporate sex as a biological variable are impacting neuroscience research. It is too soon to know whether this change justifies the administrative and financial burdens that it imposes; however, the potential gains in fundamental knowledge and therapeutic target identification are likely to outweigh the potential costs.

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Correspondence to Margaret M. McCarthy.

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Canadian Institute of Health Research Sex, Gender and Health Research Guide

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McCarthy, M., Woolley, C. & Arnold, A. Incorporating sex as a biological variable in neuroscience: what do we gain?. Nat Rev Neurosci 18, 707–708 (2017).

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