Although some lines of evidence suggest that neurogenesis in the adult hippocampus involves neural stem cells (NSCs) that can differentiate into oligodendrocytes, neurons and astrocytes, fate-mapping studies suggest that only astrocytes and neurons are generated. Here, conditional inactivation of neurofibromin (NF1) resulted in the generation of a large number of oligodendrocyte precursor cells (OPCs) that were not present in controls, suggesting that NF1 actively suppresses the OPC-producing potential of NSCs in the mature hippocampus.
Sun, G. J. et al. Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation. Nat. Neurosci. 18, 1722–1724 (2015)
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Lewis, S. Unlocking your full potential. Nat Rev Neurosci 17, 4 (2016). https://doi.org/10.1038/nrn.2015.13