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Stem cells

Unlocking your full potential

Although some lines of evidence suggest that neurogenesis in the adult hippocampus involves neural stem cells (NSCs) that can differentiate into oligodendrocytes, neurons and astrocytes, fate-mapping studies suggest that only astrocytes and neurons are generated. Here, conditional inactivation of neurofibromin (NF1) resulted in the generation of a large number of oligodendrocyte precursor cells (OPCs) that were not present in controls, suggesting that NF1 actively suppresses the OPC-producing potential of NSCs in the mature hippocampus.

References

  1. Sun, G. J. et al. Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation. Nat. Neurosci. 18, 1722–1724 (2015)

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Lewis, S. Unlocking your full potential. Nat Rev Neurosci 17, 4 (2016). https://doi.org/10.1038/nrn.2015.13

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