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Strength in diversity


A diverse set of genomes is described in this month's column, all of which are involved at some level in interactions with a human host. These range from the eukaryotic intracellular pathogen Cryptosporidium parvum, through the prokaryotic opportunistic pathogens Bacillus cereus and Leptospira interrogans, to the gut commensal Lactobacillus johnsonii. The genomes of these organisms display a wide range of adaptive responses to the challenges of survival in the mammalian host and many other environmental niches.

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  1. 1

    Abrahamsen, M. S. et al. Complete genome sequence of the apicomplexan, Cryptosporidium parvum. Science (25 March 2004) doi: 10.1126/science.1094786.

  2. 2

    Gardner, M. J. et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419, 498–511 (2002).

    CAS  Article  Google Scholar 

  3. 3

    Nascimento, A. L. et al. Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis. J. Bacteriol. 186, 2164–2172 (2004).

    CAS  Article  Google Scholar 

  4. 4

    Pridmore, R. D. et al. The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533. Proc. Natl Acad. Sci. USA 101, 2512–2517 (2004).

    CAS  Article  Google Scholar 

  5. 5

    Xu, J. et al. A genomic view of the human–Bacteroides thetaiotaomicron symbiosis. Science 299, 2074–2076 (2003).

    CAS  Article  Google Scholar 

  6. 6

    Rasko, D. A. et al. The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pX01. Nucleic Acids Res. 32, 977–988 (2004).

    CAS  Article  Google Scholar 

  7. 7

    Ivanova, N. et al. Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis. Nature 423, 87–91 (2003).

    CAS  Article  Google Scholar 

  8. 8

    Read, T. D. et al. The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria. Nature 423, 81–86 (2003).

    CAS  Article  Google Scholar 

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Bacillus anthracis

Bacillus cereus

Bacteroides thetaiotaomicron

Lactobacillus johnsonii

Leptospira serovar Copenhageni

Leptospira serovar Lai


Cryptosporidium parvum genome project

Plasmodium falciparum genome project

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Pain, A., Crossman, L., Sebaihia, M. et al. Strength in diversity. Nat Rev Microbiol 2, 358–359 (2004).

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