Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Strength in diversity

Abstract

A diverse set of genomes is described in this month's column, all of which are involved at some level in interactions with a human host. These range from the eukaryotic intracellular pathogen Cryptosporidium parvum, through the prokaryotic opportunistic pathogens Bacillus cereus and Leptospira interrogans, to the gut commensal Lactobacillus johnsonii. The genomes of these organisms display a wide range of adaptive responses to the challenges of survival in the mammalian host and many other environmental niches.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1
Figure 2

References

  1. 1

    Abrahamsen, M. S. et al. Complete genome sequence of the apicomplexan, Cryptosporidium parvum. Science (25 March 2004) doi: 10.1126/science.1094786.

  2. 2

    Gardner, M. J. et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419, 498–511 (2002).

    CAS  Article  Google Scholar 

  3. 3

    Nascimento, A. L. et al. Comparative genomics of two Leptospira interrogans serovars reveals novel insights into physiology and pathogenesis. J. Bacteriol. 186, 2164–2172 (2004).

    CAS  Article  Google Scholar 

  4. 4

    Pridmore, R. D. et al. The genome sequence of the probiotic intestinal bacterium Lactobacillus johnsonii NCC 533. Proc. Natl Acad. Sci. USA 101, 2512–2517 (2004).

    CAS  Article  Google Scholar 

  5. 5

    Xu, J. et al. A genomic view of the human–Bacteroides thetaiotaomicron symbiosis. Science 299, 2074–2076 (2003).

    CAS  Article  Google Scholar 

  6. 6

    Rasko, D. A. et al. The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pX01. Nucleic Acids Res. 32, 977–988 (2004).

    CAS  Article  Google Scholar 

  7. 7

    Ivanova, N. et al. Genome sequence of Bacillus cereus and comparative analysis with Bacillus anthracis. Nature 423, 87–91 (2003).

    CAS  Article  Google Scholar 

  8. 8

    Read, T. D. et al. The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria. Nature 423, 81–86 (2003).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Related links

Related links

DATABASES

Entrez

Bacillus anthracis

Bacillus cereus

Bacteroides thetaiotaomicron

Lactobacillus johnsonii

Leptospira serovar Copenhageni

Leptospira serovar Lai

FURTHER INFORMATION

Cryptosporidium parvum genome project

Plasmodium falciparum genome project

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Pain, A., Crossman, L., Sebaihia, M. et al. Strength in diversity. Nat Rev Microbiol 2, 358–359 (2004). https://doi.org/10.1038/nrmicro889

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing