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Molecular Koch's postulates applied to bacterial pathogenicity — a personal recollection 15 years later

Nature Reviews Microbiology volume 2, pages 67–72 (2004)Cite this article

Abstract

Koch's postulates were derived from Robert Koch's work on infectious diseases, such as anthrax and tuberculosis, which still engage us to this day. These guidelines were an attempt to establish a standard for identifying the specific causation of an infectious disease and to convince sceptics that microorganisms could cause disease. They were also established to encourage an increasing number of novice microbiologists to use more rigorous criteria before claiming a causal relationship between a microorganism and a disease.

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Figure 1: The use of gene knockout animals to help determine virulence gene function.
Figure 2: The use of the host response to infection to define the function of bacterial virulence genes.

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Acknowledgements

I would like to acknowledge D. Monack, I. Brodsky and E. Joyce for reading the manuscript and providing me with their fresh insights about the 'postulates'.

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  1. Stanford University School of Medicine, Stanford, 94305-5124, California, USA

    Stanley Falkow

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  1. Stanley Falkow
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Falkow, S. Molecular Koch's postulates applied to bacterial pathogenicity — a personal recollection 15 years later. Nat Rev Microbiol 2, 67–72 (2004). https://doi.org/10.1038/nrmicro799

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