With the number of published microbial genomes now in excess of 100, any new genome that is sequenced is likely to have a close relative available for comparison. Indeed, it is increasingly difficult to perform any genomic analysis that is not comparative. This should, however, not be seen as a drawback; it is often the case that a large amount of information can be drawn from these comparisons, especially between closely related organisms. Several genome sequences published recently indicate the value of comparisons at the genomic level.
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Thomson, N., Sebaihia, M., Cerdeño-Tárraga, A. et al. The value of comparison. Nat Rev Microbiol 1, 11–12 (2003). https://doi.org/10.1038/nrmicro734
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