Found in translation

Article metrics

This month's Genome Watch highlights a recent study that used high-throughput sequencing to identify the mRNAs that are actively translated during the life cycle of a protozoan parasite.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    Ingolia, N. T. et al. Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. Science 324, 218–223 (2009).

  2. 2

    Vasquez, J.-J. et al. Comparative ribosome profiling reveals extensive translational complexity in different Trypanosoma brucei life cycle stages. Nucl. Acids Res. (2014).

  3. 3

    Capewell, P. et al. Regulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host. PLoS ONE 8, e67069 (2013).

  4. 4

    Brecht, M. & Parsons, M. Changes in polysome profiles accompany trypanosome development. Mol. Biochem. Parasitol. 97, 189–198 (1998).

  5. 5

    Alsford, S. & Horn D. Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei. Mol. Biochem. Parasitol. 161, 76–79 (2008).

Download references

Author information

Correspondence to Lia Chappell.

Ethics declarations

Competing interests

The author declares no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Chappell, L. Found in translation. Nat Rev Microbiol 12, 238 (2014) doi:10.1038/nrmicro3243

Download citation