Found in translation

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This month's Genome Watch highlights a recent study that used high-throughput sequencing to identify the mRNAs that are actively translated during the life cycle of a protozoan parasite.

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References

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    Ingolia, N. T. et al. Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling. Science 324, 218–223 (2009).

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    Vasquez, J.-J. et al. Comparative ribosome profiling reveals extensive translational complexity in different Trypanosoma brucei life cycle stages. Nucl. Acids Res. http://dx.doi.org/10.1093/nar/gkt1386 (2014).

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    Capewell, P. et al. Regulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host. PLoS ONE 8, e67069 (2013).

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    Brecht, M. & Parsons, M. Changes in polysome profiles accompany trypanosome development. Mol. Biochem. Parasitol. 97, 189–198 (1998).

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    Alsford, S. & Horn D. Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei. Mol. Biochem. Parasitol. 161, 76–79 (2008).

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Correspondence to Lia Chappell.

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Chappell, L. Found in translation. Nat Rev Microbiol 12, 238 (2014) doi:10.1038/nrmicro3243

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