Abstract
This month's Genome Watch looks back over the past 10 years and highlights how the incredible advances in sequencing technologies have transformed research into microbial genomes.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
BMX: a tool for computing bacterial phyletic composition from orthologous maps
BMC Research Notes Open Access 24 February 2015
-
Metagenomic analyses of bacteria on human hairs: a qualitative assessment for applications in forensic science
Investigative Genetics Open Access 16 December 2014
-
Proteomic tools to decipher microbial community structure and functioning
Environmental Science and Pollution Research Open Access 05 December 2014
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Nelson, K. E. et al. Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83. J. Bacteriol. 185, 5591–5601 (2003).
Read, T. D. et al. The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria. Nature 423, 81–86 (2003).
Welch, R. A. et al. Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli. Proc. Natl Acad. Sci. USA 99, 17020–17024 (2002).
Read, T. D. et al. Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis. Science 296, 2028–2033 (2002).
Parkhill, J. et al. Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nature Genet. 35, 32–40 (2003).
Tyson, G. W. et al. Community structure and metabolism through reconstruction of microbial genomes from the environment. Nature 428, 37–43 (2004).
McLean, J. S. et al. Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform. Genome Res. 23, 867–877 (2013).
He, M. et al. Emergence and global spread of epidemic healthcare-associated Clostridium difficile. Nature Genet. 45, 109–113 (2013).
Qin, J. et al. A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 55–60 (2012).
Harris, S. R. et al. Whole-genome sequencing for analysis of an outbreak of meticillin-resistant Staphylococcus aureus: a descriptive study. Lancet Infect. Dis. 13, 130–136 (2013).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
J.P. has received funding for conference travel and accommodation from Illumina Inc.
Rights and permissions
About this article
Cite this article
Parkhill, J. What has high-throughput sequencing ever done for us?. Nat Rev Microbiol 11, 664–665 (2013). https://doi.org/10.1038/nrmicro3112
Published:
Issue Date:
DOI: https://doi.org/10.1038/nrmicro3112
This article is cited by
-
BMX: a tool for computing bacterial phyletic composition from orthologous maps
BMC Research Notes (2015)
-
Twenty years of bacterial genome sequencing
Nature Reviews Microbiology (2015)
-
Proteomic tools to decipher microbial community structure and functioning
Environmental Science and Pollution Research (2015)
-
Metagenomic analyses of bacteria on human hairs: a qualitative assessment for applications in forensic science
Investigative Genetics (2014)