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Extreme sweetness: protein glycosylation in archaea

Nature Reviews Microbiology volume 11, pages 151–156 (2013)Cite this article

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Abstract

Although N-glycosylation was first reported in archaea almost 40 years ago, detailed insights into this process have become possible only recently, with the availability of complete genome sequences for almost 200 archaeal species and the development of appropriate molecular tools. As a result of these advances, recent efforts have not only succeeded in delineating the pathways involved in archaeal N-glycosylation, but also begun to reveal how such post-translational protein modification helps archaea to survive in some of the harshest environments on the planet.

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Figure 1: The diversity of N-linked glycans decorating archaeal glycoproteins.
Figure 2: N-glycosylation pathways in archaea.

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Acknowledgements

Work in the author's laboratory is supported by the Israel Science Foundation (grant 8/11) and the US Army Research Office (W911NF-11-1-520).

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  1. Jerry Eichler is at the Department of Life Sciences, Ben Gurion University of the Negev, P.O. Box 653, Beersheva 84105, Israel.,

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Eichler, J. Extreme sweetness: protein glycosylation in archaea. Nat Rev Microbiol 11, 151–156 (2013). https://doi.org/10.1038/nrmicro2957

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